{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:14:00Z","timestamp":1780503240256,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T00:00:00Z","timestamp":1411776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"12th five year research project of military medical science and technology key project","award":["BWS11J058"],"award-info":[{"award-number":["BWS11J058"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Conventional methods of screening for Hirschsprung disease (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) in newborns (barium enema, <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content>; anorectal manometry, <jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content>; rectal suction biopsy, <jats:styled-content style=\"fixed-case\">RSB<\/jats:styled-content>) have limitations and\/or are invasive. High\u2010resolution anorectal manometry (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content>) is a minimally invasive technique that has potential to overcome most of these limitations, but normative data and performance characteristics have not been reported in newborns. The aims of our study were to assess anorectal sphincter metrics including resting pressure (<jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>), anal canal length (<jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content>), and rectoanal inhibitory reflex (<jats:styled-content style=\"fixed-case\">RAIR<\/jats:styled-content>) in healthy and asymptomatic newborns, and to explore the role of <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> in the diagnosis of <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> using these normal parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All procedures were performed using solid state <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> equipment (Medical Measurement Systems, Enchede, The Netherland) by a single operator. In the first phase, 180 asymptomatic newborns (term newborns 95, preterm newborns 85) were studied, and anal <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ACL<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">RAIR<\/jats:styled-content> were measured. In the second phase, 16 newborns with clinical manifestations of <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> were studied (9 of whom had histopathologic confirmation), and parameters compared to asymptomatic newborns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Normative <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content> values were higher in term newborns compared with preterm newborns (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), and correlated with age. Progressive maturation of the anal sphincter was evident with chronologic age, both in preterm and term newborns. <jats:styled-content style=\"fixed-case\">RAIR<\/jats:styled-content> was present in all normal subjects. Using absent <jats:styled-content style=\"fixed-case\">RAIR<\/jats:styled-content> as indicative of <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> had a sensitivity 89% and specificity of 83% compared to <jats:styled-content style=\"fixed-case\">RSB<\/jats:styled-content>; these performance characteristics were better than <jats:styled-content style=\"fixed-case\">BE<\/jats:styled-content> (sensitivity 78%, specificity 17%), with significantly higher diagnostic accuracy (80% <jats:italic>vs<\/jats:italic> 53%, respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Anorectal sphincter pressure progressively matures with incremental increase in <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content> during the first months of life. <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content> is an effective and safe method that complements the diagnosis of <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> in newborns.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12423","type":"journal-article","created":{"date-parts":[[2014,9,27]],"date-time":"2014-09-27T04:52:45Z","timestamp":1411793565000},"page":"1565-1572","source":"Crossref","is-referenced-by-count":50,"title":["High\u2010resolution anorectal manometry in newborns: normative values and diagnostic utility in <scp>H<\/scp>irschsprung disease"],"prefix":"10.1111","volume":"26","author":[{"given":"Y.\u2010F.","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The General Hospital of Beijing Military Command Beijing China"},{"name":"Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010G.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery The Eighth Hospital Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010J.","family":"An","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The General Hospital of Beijing Military Command Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The General Hospital of Beijing Military Command Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The General Hospital of Beijing Military Command Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.\u2010F.","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The General Hospital of Beijing Military Command Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.\u2010M.","family":"Huang","sequence":"additional","affiliation":[{"name":"Ba Yi Children's Hospital The General Hospital of Beijing Military Command Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010W.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The General Hospital of Beijing Military Command Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.\u2010Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The General Hospital of Beijing Military Command Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.\u2010Y.","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The General Hospital of Beijing Military Command Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010J.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The General Hospital of Beijing Military Command Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The General Hospital of Beijing Military Command Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010H.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The General Hospital of Beijing Military Command Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. P.","family":"Gyawali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010Q.","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The General Hospital of Beijing Military Command Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.11.729"},{"key":"e_1_2_10_3_1","volume-title":"Hirschsprung's disease and Allied Disorders","author":"Holschneider AM","year":"2000"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/01.sla.0000089854.00436.cd","article-title":"One\u2010stage transanal Soave pullthrough for Hirschsprung disease: a multicenter experience with 141 children","volume":"238","author":"Langer JC","year":"2003","journal-title":"Ann Surg"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2003.50070"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000150420.00161.B9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-007-0026-z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.01.044"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470000298"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182a8bb50"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-004-1292-7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/jpsu.2003.50165"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9261.70640"},{"key":"e_1_2_10_14_1","first-page":"40","article-title":"Anorectal manometry in the neonatal diagnosis of Hirschsprung's disease","volume":"23","author":"Enriquez Zarabozo E","year":"2010","journal-title":"Cir Pediatr"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.06.004"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.361"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.01.008"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01069.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2012.11680810"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-008-2293-7"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(67)80011-3"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00526.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016967"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301145"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000214164.90939.92"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.115969"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00497-9"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12423","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T15:22:59Z","timestamp":1696173779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,27]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/nmo.12423"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12423","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,27]]}}}