{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:45:18Z","timestamp":1789731918112,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Postprandial discomfort following intake of poorly absorbable, but fermentable carbohydrates is a common complaint in patients with irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>). We used lactulose as a model substance for this group of symptom triggering carbohydrates, aiming to visualize the intestinal response in <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients compared to healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> according to <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ome III criteria (<jats:italic>n<\/jats:italic>\u00a0=\u00a052) and healthy controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a016) underwent a lactulose challenge test. By using magnetic resonance imaging, we measured small bowel water content (<jats:styled-content style=\"fixed-case\">SBWC<\/jats:styled-content>), and distension (diameter) of the distal ileum and the colon, both in fasting state and 1\u00a0h after ingestion of 10\u00a0g lactulose. We recorded symptoms after lactulose ingestion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Lactulose provoked significantly more symptoms in <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients than in healthy controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). <jats:styled-content style=\"fixed-case\">SBWC<\/jats:styled-content> increased more in the patient group compared to the control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0005). The postprandial diameter of the terminal ileum was larger in patients with <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> and the postprandial diameter of the ascending colon was smaller in patients with diarrhea\u2010predominant phenotype (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010D). Symptoms were not correlated with change in <jats:styled-content style=\"fixed-case\">SBWC<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.05; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.11), nor to the diameters of the terminal ileum or the colon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Compared to healthy controls, <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients developed more symptoms and had an abnormal accumulation of fluid in the small bowel in response to ingestion of the unabsorbable carbohydrate lactulose. This may be due to impaired motor activity of the small intestine or impaired function of the ileocecal segment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12449","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T10:47:20Z","timestamp":1412160440000},"page":"1686-1693","source":"Crossref","is-referenced-by-count":34,"title":["Abnormal accumulation of intestinal fluid following ingestion of an unabsorbable carbohydrate in patients with irritable bowel syndrome: an <scp>MRI<\/scp> study"],"prefix":"10.1111","volume":"26","author":[{"given":"R.","family":"Undseth","sequence":"first","affiliation":[{"name":"Department of Radiology Lovisenberg Diakonale Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Berstad","sequence":"additional","affiliation":[{"name":"Department of Medicine Unger\u2010Vetlesen's Institute Lovisenberg Diakonale Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.\u2010E.","family":"Kl\u00f8w","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Oslo University Hospital University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Arnljot","sequence":"additional","affiliation":[{"name":"Department of Radiology Lovisenberg Diakonale Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. S.","family":"Moi","sequence":"additional","affiliation":[{"name":"Department of Radiology Lovisenberg Diakonale Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Valeur","sequence":"additional","affiliation":[{"name":"Department of Medicine Unger\u2010Vetlesen's Institute Lovisenberg Diakonale Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.029"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.690045"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199805000-00011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327558ijbm1303_4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.105"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2010.12.012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.259"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365520903348684"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.75"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04237.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/52\/23\/009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.386"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.142318000.x"},{"key":"e_1_2_10_16_1","first-page":"945","article-title":"Lactulose\u2013a multifaceted substance","volume":"35","author":"Huchzermeyer H","year":"1997","journal-title":"Z Gastroenterol"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.10.055"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90053-X"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70577-3"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01823.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.105"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.031"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00726-8"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2013.01.008"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i9.2383"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12243"},{"issue":"1","key":"e_1_2_10_27_1","first-page":"A110","article-title":"FODMAP\u2010intolerance in IBS: visualization by magnetic resonance imaging","volume":"1","author":"Undseth R","year":"2013","journal-title":"United Eur Gastroenterol J"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12449","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T20:44:28Z","timestamp":1696193068000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/nmo.12449"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12449","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}