{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:59:01Z","timestamp":1773680341512,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T00:00:00Z","timestamp":1414368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antireflux therapy may lead to recovery of impaired mucosal integrity in gastro\u2010esophageal reflux disease (<jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>) patients as reflected by an increase in baseline impedance. The study objective was to evaluate the effect of endoscopic fundoplication and proton pump inhibitor (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> therapy on baseline impedance and heartburn severity in <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010seven <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients randomized to endoscopic fundoplication (<jats:italic>n<\/jats:italic>\u00a0=\u00a032) or <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> therapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a015), and 29 healthy controls were included. Before randomization and 6\u00a0months after treatment, baseline impedance was obtained during 24\u2010h pH\u2010impedance monitoring. Heartburn severity was evaluated using the <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HRQL<\/jats:styled-content> questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Before treatment, baseline impedance in <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients was lower than in healthy controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Antireflux therapy increased baseline impedance (from 1498 [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 951\u20132472] to 2393 [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 1353\u20133027] \u03a9, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), however it only led to a partial recovery when compared to healthy controls (2393 [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 1353\u20133027] <jats:italic>vs<\/jats:italic> 2983 [2335\u20133810] \u03a9, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). The effect of both treatment options was not significantly different (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.13) despite the increased number of non\u2010acid reflux events in the <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> group. No correlation was found between baseline impedance and <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> symptoms before or after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Reduction in acid reflux by endoscopic fundoplication or <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> therapy leads to an increase in baseline impedance in <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content> patients, likely to reflect recovery of mucosal integrity. The impact of non\u2010acid reflux events on esophageal mucosal integrity may be limited as no difference in the increase in baseline impedance was observed after both treatment options. The lack of association between impedance baseline and heartburn severity indicates that other factors may contribute to heartburn perception in <jats:styled-content style=\"fixed-case\">GERD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12468","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T04:25:44Z","timestamp":1414470344000},"page":"220-228","source":"Crossref","is-referenced-by-count":41,"title":["The effect of endoscopic fundoplication and proton pump inhibitors on baseline impedance and heartburn severity in <scp>GERD<\/scp> patients"],"prefix":"10.1111","volume":"27","author":[{"given":"N. F.","family":"Rinsma","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Farr\u00e9","sequence":"additional","affiliation":[{"name":"Translational Research Center for Gastrointestinal Disorders Catholic University Leuven Leuven Belgium"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. D.","family":"Bouvy","sequence":"additional","affiliation":[{"name":"Department of Surgery Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A. 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