{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:15:11Z","timestamp":1791281711427,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,26]],"date-time":"2014-10-26T00:00:00Z","timestamp":1414281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natural Scientific Foundation of China","award":["30971074"],"award-info":[{"award-number":["30971074"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oxytocin plays an analgesic role in modulation of nociception and pain. Most work to date has focused on the central mechanisms of oxytocin analgesia, but little is known about whether peripheral mechanisms are also involved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The mesenteric afferent discharge was recorded <jats:italic>in vitro<\/jats:italic>. The expressions of oxytocin receptor (<jats:styled-content style=\"fixed-case\">OTR<\/jats:styled-content>) and neuronal nitric oxide synthase (<jats:styled-content style=\"fixed-case\">nNOS<\/jats:styled-content>) in longitudinal muscle myenteric plexus (<jats:styled-content style=\"fixed-case\">LMMP<\/jats:styled-content>) was identified by immunofluorescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Oxytocin <jats:italic>per se<\/jats:italic> had no effect on the jejunal mesenteric afferent discharge, however, it markedly attenuated the bradykinin\u2010 or distention\u2010evoked increase of mesenteric afferent discharge, which was mimiced by the nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>) donor sodium nitroprusside (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>). Pretreatment of either <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content> inhibitor L\u2010<jats:styled-content style=\"fixed-case\">NAME<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">NPLA<\/jats:styled-content> largely reduced the inhibitory effect of oxytocin on bradykinin\u2010evoked mesenteric afferent discharge. Such effect, to a large extent, was also alleviated by N\u2010and P\u2010type voltage\u2010dependent calcium channel antagonists or K<jats:sub>ATP<\/jats:sub> blocker glibenclamide. In addition, immunofluorescence studies show strong colocalization of <jats:styled-content style=\"fixed-case\">OTR<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">nNOS<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">LMMP<\/jats:styled-content> of the rat jejunum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Oxytocin down\u2010regulates the mesenteric afferent sensitivity through <jats:styled-content style=\"fixed-case\">nNOS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>\u2010K<jats:sub>ATP<\/jats:sub> pathway. Our findings may reveal a new peripheral mechanism for oxytocin analgesia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12469","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T02:43:53Z","timestamp":1414377833000},"page":"51-62","source":"Crossref","is-referenced-by-count":24,"title":["Oxytocin down\u2010regulates mesenteric afferent sensitivity via the enteric <scp>OTR<\/scp>\/<scp>nNOS<\/scp>\/<scp>NO<\/scp>\/K<sub>ATP<\/sub> pathway in rat"],"prefix":"10.1111","volume":"27","author":[{"given":"J.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Physiology Shandong Provincial Key Laboratory of Mental Disorders Shandong University School of Medicine Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Physiology Shandong Provincial Key Laboratory of Mental Disorders Shandong University School of Medicine Jinan 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