{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:10:35Z","timestamp":1791573035006,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T00:00:00Z","timestamp":1417564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut national de la sant\u00e9 et de la recherche m\u00e9dicale","doi-asserted-by":"publisher","award":["DK056033"],"award-info":[{"award-number":["DK056033"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The Chicago Classification (\n CC<\/jats:styled-content>\n ) of esophageal motility disorders, utilizing an algorithmic scheme to analyze clinical high\u2010resolution manometry (\n HRM<\/jats:styled-content>\n ) studies, has gained acceptance worldwide.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This 2014 update,\n CC<\/jats:styled-content>\n v3.0, developed by the International\n HRM<\/jats:styled-content>\n Working Group, incorporated the extensive clinical experience and interval publications since the prior (2011) version.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n Chicago Classification v3.0 utilizes a hierarchical approach, sequentially prioritizing: (i) disorders of esophagogastric junction (\n EGJ<\/jats:styled-content>\n ) outflow (achalasia subtypes I\u2010III and\n EGJ<\/jats:styled-content>\n outflow obstruction), (ii) major disorders of peristalsis (absent contractility, distal esophageal spasm, hypercontractile esophagus), and (iii) minor disorders of peristalsis characterized by impaired bolus transit.\n EGJ<\/jats:styled-content>\n morphology, characterized by the degree of overlap between the lower esophageal sphincter and the crural diaphragm and baseline\n EGJ<\/jats:styled-content>\n contractility are also part of\n CC<\/jats:styled-content>\n v3.0. Compared to the previous\n CC<\/jats:styled-content>\n version, the key metrics of interpretation, the integrated relaxation pressure (\n IRP<\/jats:styled-content>\n ), the distal contractile integral (\n DCI<\/jats:styled-content>\n ), and the distal latency (\n DL<\/jats:styled-content>\n ) remain unchanged, albeit with much more emphasis on\n DCI<\/jats:styled-content>\n for defining both hypo\u2010 and hypercontractility. New in\n CC<\/jats:styled-content>\n v3.0 are: (i) the evaluation of the\n EGJ<\/jats:styled-content>\n at rest defined in terms of morphology and contractility, (ii) \u2018fragmented\u2019 contractions (large breaks in the 20\u2010mmHg isobaric contour), (iii) ineffective esophageal motility (\n IEM<\/jats:styled-content>\n ), and (iv) several minor adjustments in nomenclature and defining criteria. Absent in\n CC<\/jats:styled-content>\n v3.0 are contractile front velocity and small breaks in the 20\u2010mmHg isobaric contour as defining characteristics.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n \n Chicago Classification v3.0 is an updated analysis scheme for clinical esophageal\n HRM<\/jats:styled-content>\n recordings developed by the International\n HRM<\/jats:styled-content>\n Working Group.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.12477","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T14:46:23Z","timestamp":1417617983000},"page":"160-174","source":"Crossref","is-referenced-by-count":1737,"title":["The Chicago Classification of esophageal motility disorders, v3.0"],"prefix":"10.1111","volume":"27","author":[{"given":"P. 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