{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:31:02Z","timestamp":1787164262362,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,6]],"date-time":"2014-12-06T00:00:00Z","timestamp":1417824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institue of Health","award":["P01 DK068055, NS44233, U54NSO65736, and UL1 TR000135"],"award-info":[{"award-number":["P01 DK068055, NS44233, U54NSO65736, and UL1 TR000135"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Gastrointestinal symptoms are common in the postural orthostatic tachycardia syndrome (\n                      <jats:styled-content style=\"fixed-case\">POTS<\/jats:styled-content>\n                      ). However, few studies have evaluated gastrointestinal transit in\n                      <jats:styled-content style=\"fixed-case\">POTS<\/jats:styled-content>\n                      . Our primary objectives were to evaluate gastrointestinal emptying and the relationship with autonomic dysfunctions in\n                      <jats:styled-content style=\"fixed-case\">POTS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We reviewed the complete medical records of all patients aged 18\u00a0years and older with\n                      <jats:styled-content style=\"fixed-case\">POTS<\/jats:styled-content>\n                      diagnosed by a standardized autonomic reflex\u00a0screen who also had a scintigraphic assessment of gastrointestinal transit at Mayo Clinic Rochester between 1998 and 2012. Associations between specific gastric emptying and autonomic (i.e., cardiovagal, adrenergic, and sudomotor) disturbances were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Among 163 patients (140 women, mean [\u00b1\n                      <jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content>\n                      ] age 30 [\u00b11] years), 55 (34%) had normal, 30 (18%) had delayed,\u00a0and 78 (48%) had rapid gastric emptying. Fifty\u2010eight patients (36%) had clinical features of physical deconditioning, which was associated (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02) with rapid gastric emptying. Associations\u00a0with delayed gastric emptying included vomiting, which was more common (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.003), and anxiety or depression, which was less common (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02). The tilt\u2010associated increase in heart rate and reduction in systolic\n                      <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n                      at 1\u00a0min was associated (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), being greater in patients with delayed gastric emptying.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>\n                      Two\u2010thirds of patients with\n                      <jats:styled-content style=\"fixed-case\">POTS<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\n                      symptoms\u00a0had abnormal, most frequently rapid gastric emptying. Except for more severe adrenergic impairment in patients with delayed gastric emptying, the pattern of autonomic dysfunction did not discriminate among gastric emptying groups. Further studies are necessary to ascertain whether extravascular volume depletion and\/or deconditioning contribute to\n                      <jats:styled-content style=\"fixed-case\">POTS<\/jats:styled-content>\n                      in patients with gastrointestinal symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12480","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T22:53:48Z","timestamp":1418079228000},"page":"92-98","source":"Crossref","is-referenced-by-count":59,"title":["Disturbances of gastrointestinal transit and autonomic functions in postural orthostatic tachycardia syndrome"],"prefix":"10.1111","volume":"27","author":[{"given":"A.","family":"Loavenbruck","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Iturrino","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Program Department of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Sletten","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"Zinsmeister","sequence":"additional","affiliation":[{"name":"Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E.","family":"Bharucha","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Program Department of Gastroenterology and Hepatology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.08.013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)61027-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.3.397"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040977"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200107000-00008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00946.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/868496"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318145a70c"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-013-0193-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.08.054"},{"key":"e_1_2_9_12_1","first-page":"11","volume-title":"Physical Activity, Fitness, and Health: International Proceedings and Consensus Statement","author":"Bouchard C","year":"1994"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01299.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-817725"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199712)20:12<1561::AID-MUS11>3.0.CO;2-3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60631-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01089.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01972.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01441.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.02.020"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03351.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01710.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-3-20"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01679.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00867.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31802bddb7"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(97)00087-8"},{"key":"e_1_2_9_28_1","first-page":"G499","article-title":"Efferent pathways in the reflex control of gastric emptying in rats","volume":"260","author":"Forster ER","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01381.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01124.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00923.x"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12480","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T18:28:42Z","timestamp":1696444122000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,6]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/nmo.12480"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12480","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,6]]}}}