{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:14:34Z","timestamp":1789560874211,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T00:00:00Z","timestamp":1418774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK069614"],"award-info":[{"award-number":["DK069614"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International Foundation for Functional GI Disorders"},{"name":"NYSTAR","award":["C020118"],"award-info":[{"award-number":["C020118"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Studies of symptomatic gastroparetics consistently find poor correlation with gastric emptying. We hypothesized that concomitant small bowel dysmotility may play a role in symptom causation in gastroparesis and sought to test this hypothesis by using wireless motility capsule (\n                      <jats:styled-content style=\"fixed-case\">WMC<\/jats:styled-content>\n                      ) testing to simultaneously measure antral and duodenal area under pressure curve (\n                      <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\n                      ) in patients with delayed gastric emptying.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using a cohort from a multicenter clinical trial and a separate tertiary clinical database, we identified gastroparetics that underwent concurrent\n                      <jats:styled-content style=\"fixed-case\">WMC<\/jats:styled-content>\n                      testing and completed the Gastroparesis Cardinal Symptom Index, a validated questionnaire. Our study included 35 gastroparetics defined by a gastric emptying time (\n                      <jats:styled-content style=\"fixed-case\">GET<\/jats:styled-content>\n                      ) \u22655\u00a0h. Antral and duodenal\n                      <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\n                      were assessed at 1\u2010h windows pre\u2010\n                      <jats:styled-content style=\"fixed-case\">GET<\/jats:styled-content>\n                      and post\u2010\n                      <jats:styled-content style=\"fixed-case\">GET<\/jats:styled-content>\n                      , respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      We found moderate correlations between duodenal\n                      <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\n                      and symptom severity in the combined cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a035;\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0\u22120.42;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u22120.7, \u22120.1). Removing patients with colonic delay resulted in a stronger correlation of duodenal\n                      <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\n                      to symptom severity (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a021;\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0\u22120.63;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u22120.81, \u22120.31). The multicenter trial (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020) and clinical practice cohorts (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a015) had significantly different symptom severity and exclusion criteria. When analyzed separately, significant correlations between duodenal\n                      <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\n                      and symptom severity were observed (\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0\u22120.71;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u22120.9, \u22120.4 and\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0\u22120.72;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01; 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u22120.9, \u22120.3, respectively). Symptom severity and antral motility showed no correlation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>\n                      We found significant correlations between duodenal\n                      <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\n                      and symptom severity in two cohorts of gastroparetics. Small bowel motility may contribute to symptom generation in gastroparetic patients and this may inform therapeutic considerations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12496","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T01:43:33Z","timestamp":1418953413000},"page":"339-346","source":"Crossref","is-referenced-by-count":33,"title":["Duodenal rather than antral motility contractile parameters correlate with symptom severity in gastroparesis patients"],"prefix":"10.1111","volume":"27","author":[{"given":"K.","family":"Barshop","sequence":"first","affiliation":[{"name":"Pritzker School of Medicine University of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Staller","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Semler","sequence":"additional","affiliation":[{"name":"Independent Contractor Buffalo NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.104"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X12437874"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01905.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.06.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03564.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-9567-x"},{"key":"e_1_2_10_9_1","volume-title":"Smartpill GI Monitoring System, version 2.0","author":"FDA","year":"2009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01879.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-010-9620-x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:QURE.0000021689.86296.e4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01862.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01517.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03683.x"},{"key":"e_1_2_10_17_1","first-page":"478","article-title":"Severity of dyspeptic symptoms correlates with delayed and early variables of gastric emptying","volume":"58","author":"Ardila\u2010Hani A","year":"2013","journal-title":"Dig Dis Sci"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006051204000511"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04162.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2013.19.3.395"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01468.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181ff0122"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31818b8ed9"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12496","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:17:25Z","timestamp":1696227445000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,17]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/nmo.12496"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12496","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725282777.793521234","asserted-by":"object"}]},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,17]]}}}