{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:15:42Z","timestamp":1790417742591,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,3]],"date-time":"2015-01-03T00:00:00Z","timestamp":1420243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1064835"],"award-info":[{"award-number":["1064835"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Slow transit constipation (<jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content>) is associated with colonic motor abnormalities. The underlying cause(s) of the abnormalities remain poorly defined. In health, utilizing high resolution fiber\u2010optic manometry, we have described a distal colonic propagating motor pattern with a slow wave frequency of 2\u20136 cycles per minute (cpm). A high calorie meal caused a rapid and significant increase in this activity, suggesting the intrinsic slow wave activity could be mediated by extrinsic neural input. Utilizing the same protocol our aim was to characterize colonic meal response <jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A fiber\u2010optic manometry catheter (72 sensors at 1\u00a0cm intervals) was colonoscopically placed with the tip clipped at the ascending or transverse colon, in 14 patients with scintigraphically confirmed <jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content>. Manometric recordings were taken, for 2\u00a0h pre and post a 700\u00a0kCal meal. Data were compared to 12 healthy adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Prior to and\/or after the meal the cyclic propagating motor pattern was identified in 13 of 14 patients. However, the meal, did not increase the cyclic motor pattern (preprandial 7.4\u00a0\u00b1\u00a07.6 <jats:italic>vs<\/jats:italic> postprandial 8.3\u00a0\u00b1\u00a04.5 per\/2\u00a0h), this is in contrast to the dramatic increase observed in health (8.3\u00a0\u00b1\u00a013.3 <jats:italic>vs<\/jats:italic> 59.1\u00a0\u00b1\u00a089.0 per\/2\u00a0h; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>In patients with <jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content> a meal fails to induce the normal increase in the distal colonic cyclic propagating motor patterns. We propose that these data may indicate that the normal extrinsic parasympathetic inputs to the colon are attenuated in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12502","type":"journal-article","created":{"date-parts":[[2015,1,3]],"date-time":"2015-01-03T07:16:31Z","timestamp":1420269391000},"page":"379-388","source":"Crossref","is-referenced-by-count":106,"title":["Colonic motor abnormalities in slow transit constipation defined by high resolution, fibre\u2010optic manometry"],"prefix":"10.1111","volume":"27","author":[{"given":"P. G.","family":"Dinning","sequence":"first","affiliation":[{"name":"Departments of Gastroenterology and Surgery Flinders Medical Centre Flinders University Bedford Park SA Australia"},{"name":"St.George Hospital Clinical School Faculty of Medicine University of New South Wales Kogarah NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wiklendt","sequence":"additional","affiliation":[{"name":"Discipline of Human Physiology Flinders University Bedford Park SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Maslen","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology and Surgery Flinders Medical Centre Flinders University Bedford Park SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Patton","sequence":"additional","affiliation":[{"name":"St.George Hospital Clinical School Faculty of Medicine University of New South Wales Kogarah NSW Australia"},{"name":"Department of Colorectal Surgery St George Hospital Kogarah NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology and Surgery Flinders Medical Centre Flinders University Bedford Park SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"Arkwright","sequence":"additional","affiliation":[{"name":"Computer Science, Engineering and Mathematics Flinders University Bedford Park SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Wattchow","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology and Surgery Flinders Medical Centre Flinders University Bedford Park SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Z.","family":"Lubowski","sequence":"additional","affiliation":[{"name":"St.George Hospital Clinical School Faculty of Medicine University of New South Wales Kogarah NSW Australia"},{"name":"Department of Colorectal Surgery St George Hospital Kogarah NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Costa","sequence":"additional","affiliation":[{"name":"Discipline of Human Physiology Flinders University Bedford Park SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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