{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:52:13Z","timestamp":1783529533945,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T00:00:00Z","timestamp":1422230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnosis of a sliding hiatal hernia is classically made with endoscopy or barium esophagogram. Spatial separation of the lower esophageal sphincter (<jats:styled-content style=\"fixed-case\">LES<\/jats:styled-content>) and diaphragm, the hallmark of hiatal hernia, can also be observed on high\u2010resolution manometry (<jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content>), but the diagnostic accuracy of this finding has not yet been investigated. To determine the diagnostic value of <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content> in the detection of hiatal hernia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content> recordings, endoscopy reports, and barium esophagograms of 90 patients were analyzed for the presence and size of a hiatal hernia. The diagnostic value of a hernia specific <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content> pressure pattern was calculated, and the agreement of <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content> with endoscopy and barium esophagogram for the assessment of hernia size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content> was found to be highly sensitive and specific for hiatal hernia detection, with a sensitivity of 92% and specificity of 95%, exceeding the sensitivity of endoscopy or radiography alone (both 73%). Patients with a hiatal hernia on <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content> were manometrically characterized by an esophagogastric junction (<jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content>) with partial or complete separation of the <jats:styled-content style=\"fixed-case\">LES<\/jats:styled-content> and crural diaphragm (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>), the latter being associated with significantly lower <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content> pressure. A cutoff value of spatial <jats:styled-content style=\"fixed-case\">LES<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> separation on <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content> of 1.85\u00a0cm yielded the optimal performance in identifying hiatal hernia. Agreement between <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content>, endoscopy, and radiography for size of hiatal hernias was good (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.74 [0.65\u20130.82]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>With <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content>, the presence or absence and size of a hiatal hernia can be assessed with greater sensitivity than with endoscopy or radiography alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12507","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T08:18:16Z","timestamp":1422260296000},"page":"293-299","source":"Crossref","is-referenced-by-count":78,"title":["Accuracy of hiatal hernia detection with esophageal high\u2010resolution manometry"],"prefix":"10.1111","volume":"27","author":[{"given":"P. W.","family":"Weijenborg","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. B.","family":"van Hoeij","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J. P. M.","family":"Smout","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Bredenoord","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.4.476"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20191"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2002.00362.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2002.00351.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01460.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.10.053"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01893120"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(96)70006-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01138.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000037799.29678.94"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2007.12.007"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)80096-8"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197105132841902"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02220466"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2008.02.003"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1344952"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2011.01314.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2050.1999.00060.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-12-977"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12507","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T19:53:45Z","timestamp":1694634825000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,26]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/nmo.12507"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12507","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,26]]}}}