{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:00:29Z","timestamp":1791475229627,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Pyloric dysfunction has been associated with gastroparesis, particularly diabetic gastroparesis. Endoscopic functional luminal imaging probe (Endo\n                      <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content>\n                      ) uses 16 sensors inside a balloon that is inflated inside a sphincter to assess physiologic characteristics. The aim of this study was to measure the pressure, diameter, cross\u2010sectional area (\n                      <jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>\n                      ), and distensibility of the pylorus using Endo\n                      <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content>\n                      in patients with gastroparesis. In addition, the relationship between pyloric pathophysiology with gastroparesis etiology, symptoms, and gastric emptying was assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Endo\n                      <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content>\n                      was performed in 54 patients (39 idiopathic gastroparesis, 15 diabetic gastroparesis). The Endo\n                      <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content>\n                      catheter was passed endoscopically so that the balloon straddled the pylorus. Pressure, diameter,\n                      <jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>\n                      , and distensibility of the pylorus were measured at 20, 30, 40, and 50\u00a0cc balloon volume.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Pyloric sphincter contour was seen best at 40\u00a0cc balloon distension (diameter 12.2\u00a0\u00b1\u00a00.44\u00a0mm,\n                      <jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>\n                      125.2\u00a0\u00b1\u00a09.15\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      , pressure 18.0\u00a0\u00b1\u00a01.23\u00a0mmHg, length 1.59\u00a0\u00b1\u00a00.34\u00a0cm, distensibility 10.7\u00a0\u00b1\u00a02.57\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      \/mmHg). There was a wide range seen in diameter (5.6\u201322.1\u00a0mm) and distensibility (1\u201355\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      \/mmHg) of the pylorus. Symptoms of early satiety and postprandial fullness were inversely correlated with pyloric sphincter diameter and\n                      <jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>\n                      . No significant difference was seen between diabetic and idiopathic gastroparetics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>\n                      Endo\n                      <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content>\n                      is a novel technique that can be used to assess pyloric physiologic characteristics. Early satiety and postprandial fullness were inversely correlated with diameter and\n                      <jats:styled-content style=\"fixed-case\">CSA<\/jats:styled-content>\n                      of the pyloric sphincter. No significant differences were seen comparing diabetic and idiopathic gastroparetics. This technology may be of benefit to help select patients with pyloric sphincter abnormalities.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12522","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T05:28:37Z","timestamp":1424755717000},"page":"524-531","source":"Crossref","is-referenced-by-count":154,"title":["Assessing pyloric sphincter pathophysiology using Endo\n                    <scp>FLIP<\/scp>\n                    in patients with gastroparesis"],"prefix":"10.1111","volume":"27","author":[{"given":"Z.","family":"Malik","sequence":"first","affiliation":[{"name":"Gastroenterology Section Department of Medicine Temple University School of Medicine Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sankineni","sequence":"additional","affiliation":[{"name":"Gastroenterology Section Department of Medicine Temple University School of Medicine Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. P.","family":"Parkman","sequence":"additional","affiliation":[{"name":"Gastroenterology Section Department of Medicine Temple University School of Medicine Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.373"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.03.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31822f3ad2"},{"issue":"5","key":"e_1_2_9_5_1","first-page":"G580","article-title":"Relation between antral motility and gastric emptying of solids and liquids in humans","volume":"249","author":"Camilleri M","year":"1985","journal-title":"Am J Physiol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(73)80092-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00866.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90262-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(05)00328-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-011-1607-6"},{"issue":"2","key":"e_1_2_9_11_1","first-page":"E189","article-title":"Through\u2010the\u2010scope transpyloric stent placement improves symptoms and gastric emptying in patients with gastroparesis","volume":"45","author":"Clarke JO","year":"2013","journal-title":"Endoscopy"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/26\/5\/019"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00311.2006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.01.069"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12130"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-012-2484-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X12470017"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12028"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13053"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-9567-x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01612.x"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12522","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T21:04:18Z","timestamp":1696194258000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,24]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/nmo.12522"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12522","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,24]]}}}