{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:02:54Z","timestamp":1772132574397,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T00:00:00Z","timestamp":1423440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To date, few animal experiments have been conducted to examine the effects and mechanisms of buspirone in inducing the relaxation of the gastric fundus. The aim of this study is to examine the effects and mechanisms of buspirone, 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>1a<\/jats:sub> receptor agonist, in the accommodation of gastric fundus muscle in an animal experimental model using guinea pigs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the current study, we performed an immunohistochemistry for 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>1a<\/jats:sub> receptors in the tissue samples collected from the stomach of guinea pig, an <jats:italic>ex vivo<\/jats:italic> experiment to examine the electrical field stimulation (<jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>)\u2010induced relaxation of the circular muscle in the gastric fundus in guinea pigs and an <jats:italic>in vivo<\/jats:italic> experiment to measure the intragastric pressure through the insertion of the balloon catheter in the fundus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Immunohistochemical stains for 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>1a<\/jats:sub> receptor could confirm the expression of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>1a<\/jats:sub> receptor in guinea pig stomach. There was a significant dose\u2010dependent inhibition of the <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>\u2010induced relaxation of fundic muscle strips following the treatment with <jats:styled-content style=\"fixed-case\">WAY<\/jats:styled-content>\u2010100635 (5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>1a<\/jats:sub> antagonist), but this was significantly improved following the treatment with buspirone. An <jats:italic>in vivo<\/jats:italic> measurement of the gastric fundic tone showed that there was a significant decrease in the intragastric pressure at same volume by pretreatment with buspirone as compared with the vehicle control, but this could be prevented with the treatment with <jats:styled-content style=\"fixed-case\">WAY<\/jats:styled-content>\u2010100635.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Based on our results, it can be concluded that buspirone is effective in relaxing the gastric fundus via 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>1a<\/jats:sub> receptor pathway in both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> experimental models using guinea pigs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12523","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T18:05:13Z","timestamp":1423764313000},"page":"532-541","source":"Crossref","is-referenced-by-count":9,"title":["The effects of 5\u2010hydroxytryptamine1a receptor agonist, buspirone on the gastric fundus accommodation in an animal model using guinea pigs"],"prefix":"10.1111","volume":"27","author":[{"given":"Y. 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