{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:20:47Z","timestamp":1789143647064,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T00:00:00Z","timestamp":1423440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["BFU2010-15401"],"award-info":[{"award-number":["BFU2010-15401"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Degranulation of peritoneal mast cells (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>s) induced by intestinal manipulation has been proposed as a pathophysiological factor in postoperative ileus (<jats:styled-content style=\"fixed-case\">POI<\/jats:styled-content>). We aimed to explore the relationship between peritoneal and colonic <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> degranulation and gastrointestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) recovery following colectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing elective laparoscopic cholecystectomy (using a laparoscope and small abdominal incisions, <jats:italic>n<\/jats:italic>\u00a0=\u00a014), and elective laparoscopic (<jats:italic>n<\/jats:italic>\u00a0=\u00a032) or open partial colectomy (through a large abdominal incision, <jats:italic>n<\/jats:italic>\u00a0=\u00a010) were studied. <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> protease tryptase and chymase were studied in peritoneal fluid at the beginning, middle, and end of each surgical intervention. Density of <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>s in colectomy samples were examined and oro\u2010caecal transit time by breath test, <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> function recovery by clinical composite endpoint <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\u20102 and association between <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> proteases and clinical recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Open and laparoscopic colectomy caused greater peritoneal release of tryptase and chymase (323.0\u00a0ng\/mL [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>: 53.05\u2013381.4] and 118.6\u00a0ng\/mL [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>: 53.60\u2013240.3]), than cholecystectomy (41.64\u00a0ng\/mL [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>: 11.17\u201390.93]) at the end of the surgical intervention. However, there were no differences between laparoscopic and open colectomy. Increased peritoneal protease release during surgery was observed in patients who developed <jats:styled-content style=\"fixed-case\">POI<\/jats:styled-content> after colectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Colorectal surgery causes protease release from peritoneal <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>s. Protease release does not differ between both types of colectomy (laparoscopy <jats:italic>vs<\/jats:italic> laparotomy). However, <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> activation is increased in colectomy patients developing <jats:styled-content style=\"fixed-case\">POI<\/jats:styled-content>. Therefore, degranulation of peritoneal <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>s as a factor contributing to human <jats:styled-content style=\"fixed-case\">POI<\/jats:styled-content> after colectomy might be considered in future studies as a target to avoid <jats:styled-content style=\"fixed-case\">POI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12525","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T18:04:57Z","timestamp":1423764297000},"page":"764-774","source":"Crossref","is-referenced-by-count":14,"title":["Peritoneal mast cell degranulation and gastrointestinal recovery in patients undergoing colorectal surgery"],"prefix":"10.1111","volume":"27","author":[{"given":"S.","family":"Berd\u00fan","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bombuy","sequence":"additional","affiliation":[{"name":"Department of Surgery Consorci Sanitari del Maresme (CSdM) \u2010 Hospital de Matar\u00f3 Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Estrada","sequence":"additional","affiliation":[{"name":"Department of Surgery Consorci Sanitari del Maresme (CSdM) \u2010 Hospital de Matar\u00f3 Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mans","sequence":"additional","affiliation":[{"name":"Department of Surgery Consorci Sanitari del Maresme (CSdM) \u2010 Hospital de Matar\u00f3 Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rychter","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Instituto de Salud Carlos III Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Clav\u00e9","sequence":"additional","affiliation":[{"name":"Department of Surgery Consorci Sanitari del Maresme (CSdM) \u2010 Hospital de Matar\u00f3 Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Instituto de Salud Carlos III Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vergara","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Instituto de Salud Carlos III Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,9]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"DelaneyC KehletHSA on behalf of the Postoperative Ileus Management Council (PIMC).Postoperative ileus: profiles Risk factors and Definitions. 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