{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T07:10:28Z","timestamp":1721545828731},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T00:00:00Z","timestamp":1426291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Colleges and universities of Shandong province science and technology plan projects","award":["J11LC17"],"award-info":[{"award-number":["J11LC17"]}]},{"name":"The Natural Science Foundation of Shandong Province","award":["ZR2011CL012"],"award-info":[{"award-number":["ZR2011CL012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) is a gaseous messenger and serves as an important neuromodulator in the central nervous system. This study aimed to clarify the role of H<jats:sub>2<\/jats:sub>S within the dorsal motor nucleus of the vagus (<jats:styled-content style=\"fixed-case\">DMV<\/jats:styled-content>) in the control of gastric function in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cystathionine <jats:italic>\u03b2<\/jats:italic>\u2010synthetase (<jats:styled-content style=\"fixed-case\">CBS<\/jats:styled-content>) is an important generator of endogenous H<jats:sub>2<\/jats:sub>S in the brain. We investigated the distribution of <jats:styled-content style=\"fixed-case\">CBS<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">DMV<\/jats:styled-content> using immunohistochemical method, and the effects of H<jats:sub>2<\/jats:sub>S on gastric motility and on gastric acid secretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CBS<\/jats:styled-content>\u2010immunoreactive (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) neurons were detected in the rostral, intermediate and caudal <jats:styled-content style=\"fixed-case\">DMV<\/jats:styled-content>, with the highest number of <jats:styled-content style=\"fixed-case\">CBS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> neurons in the caudal <jats:styled-content style=\"fixed-case\">DMV<\/jats:styled-content>, and the lowest in the intermediate <jats:styled-content style=\"fixed-case\">DMV<\/jats:styled-content>. We also found that microinjection of the exogenous H<jats:sub>2<\/jats:sub>S donor Na<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> (0.04 and 0.08\u00a0mol\/L; 0.1\u00a0<jats:italic>\u03bc<\/jats:italic>L; <jats:italic>n<\/jats:italic>\u00a0=\u00a06; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) into the <jats:styled-content style=\"fixed-case\">DMV<\/jats:styled-content> significantly inhibited gastric motility with a dose\u2010dependent trend, and promoted gastric acid secretion in Wistar rats. Microinjection of the same volume of physiological saline (<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>; 0.1\u00a0<jats:italic>\u03bc<\/jats:italic>L, <jats:italic>n<\/jats:italic>\u00a0=\u00a06, <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05) at the same location did not noticeably change gastric motility and acid secretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>The data from these experiments suggest that the <jats:styled-content style=\"fixed-case\">CBS<\/jats:styled-content> that produces H<jats:sub>2<\/jats:sub>S is present in the <jats:styled-content style=\"fixed-case\">DMV<\/jats:styled-content>, and microinjection of Na<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> into the <jats:styled-content style=\"fixed-case\">DMV<\/jats:styled-content> inhibited gastric motility and enhanced gastric acid secretion in rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12530","type":"journal-article","created":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T07:44:13Z","timestamp":1426319053000},"page":"618-626","source":"Crossref","is-referenced-by-count":6,"title":["Role of hydrogen sulfide within the dorsal motor nucleus of the vagus in the control of gastric function in rats"],"prefix":"10.1111","volume":"27","author":[{"given":"H.\u2010Z.","family":"Sun","sequence":"first","affiliation":[{"name":"College of Life Science Qi Lu Normal University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.\u2010H.","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Resistance College of Life Science Shandong Normal University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010B.","family":"Ai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Resistance College of Life Science Shandong 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