{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T23:41:33Z","timestamp":1778024493424,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T00:00:00Z","timestamp":1424304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China (973 Program)","doi-asserted-by":"crossref","award":["NO.2012CB518501"],"award-info":[{"award-number":["NO.2012CB518501"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"New Century Outstanding Talents Support Program of Education Ministry of China"},{"name":"Youth Foundation of National Natural Science Foundation of China","award":["NO.81001504"],"award-info":[{"award-number":["NO.81001504"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the similarities and differences in cerebral responses to puncturing at different acupoints for treating meal\u2010related functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty right\u2010handed <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients were enrolled and randomized divided into two groups. Each patient received 20 sessions\u2019 electro\u2010acupuncture treatment. The acupoints used in Group A were four acupoints on the Stomach Meridian, and the acupoints used in Group B were four acupoints on the Gallbladder Meridian. <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scans were performed before and after acupuncture treatment to record the changes of cerebral glycometabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>After treatment, the dyspepsia symptoms and the quality of life (<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>) of the patients in each group were significantly improved (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and there was insignificant difference in efficacy between the two groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). In Group A, deactivation in brainstem, bilateral anterior cingulate cortex (<jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>) and cerebellum, left superior medial frontal gyrus, orbital frontal cortex (<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>), and thalamus, etc., and activation in bilateral middle cingulate cortex (<jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content>), precuneus and lingual gyrus, etc. were observed. In Group B, deactivation in brainstem, bilateral thalamus, putamen, <jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>, postterior cingulate cortex, hippocampus and cerebellum, etc., and activation in bilateral <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content>, precuneus, left <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>, etc. were observed (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05, Family\u2010wise error corrected).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Different acupoints have similar clinical efficacy but relatively different cerebral responses. The influence on the sensory transduction regions (brainstem and thalamus) and visceral modulation regions might be the common mechanism of different acupoints treating for <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>, and the modulation on some emotion\/cognition\u2010related areas (e.g., prefrontal cortex) is the potential difference between the different acupoints.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12532","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T07:14:49Z","timestamp":1424330089000},"page":"559-568","source":"Crossref","is-referenced-by-count":30,"title":["Cerebral responses to puncturing at different acupoints for treating meal\u2010related functional dyspepsia"],"prefix":"10.1111","volume":"27","author":[{"given":"F.","family":"Zeng","sequence":"first","affiliation":[{"name":"Acupunture and Tuina School\/The 3<sup>rd<\/sup> Teaching Hospital Chengdu University of Traditional Chinese Medicine Chengdu 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