{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:29:50Z","timestamp":1792542590094,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007872","name":"Bowel and Cancer Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007872","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ehlers-Danlos Syndrome Support UK"},{"name":"Pseudo-obstruction Research Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The overlap of unexplained gastrointestinal (\n GI<\/jats:styled-content>\n ) and somatic symptoms is well established in patients with functional gastrointestinal disorders (\n FGID<\/jats:styled-content>\n ). Joint hypermobility syndrome (\n JHS<\/jats:styled-content>\n ) is a non\u2010inflammatory connective tissue disorder associated with\n GI<\/jats:styled-content>\n and somatic symptoms. We aimed to determine whether there is an association between diagnosis of\n JHS<\/jats:styled-content>\n and\n FGID<\/jats:styled-content>\n and the impact of this association on comorbidities and quality of life (\n QOL<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Prospective case\u2013control study in secondary care\n GI<\/jats:styled-content>\n clinics over 2\u00a0years.\n JHS<\/jats:styled-content>\n was assessed by the first author prior to consultation in 641 consecutive new patients. Diagnosis of\n FGID<\/jats:styled-content>\n (cases,\n n<\/jats:italic>\n \u00a0=\u00a0336) or organic disorders (controls,\n n<\/jats:italic>\n \u00a0=\u00a0305) was established blind to\n JHS<\/jats:styled-content>\n status.\n JHS<\/jats:styled-content>\n prevalence was compared in cases (\n FGID<\/jats:styled-content>\n patients) and controls (organic disorders patients). Extra\u2010intestinal comorbidity and\n QOL<\/jats:styled-content>\n were compared in\n FGID<\/jats:styled-content>\n patients with and without\n JHS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n JHS<\/jats:styled-content>\n prevalence was higher in\n FGID<\/jats:styled-content>\n compared to organic\n GI<\/jats:styled-content>\n disorders (39.0%\n vs<\/jats:italic>\n 27.5%,\n OR<\/jats:styled-content>\n adj: 1.51,\n CI<\/jats:styled-content>\n : 1.07\u20132.12,\n p<\/jats:italic>\n \u00a0=\u00a00.02), and particularly associated with functional gastroduodenal disorders (44.1%,\n OR<\/jats:styled-content>\n adj: 2.08,\n CI<\/jats:styled-content>\n : 1.25\u20133.46,\n p<\/jats:italic>\n \u00a0=\u00a00.005), specifically postprandial distress syndrome (51%,\n OR<\/jats:styled-content>\n adj: 1.99,\n CI<\/jats:styled-content>\n : 1.06\u20133.76,\n p<\/jats:italic>\n \u00a0=\u00a00.03).\n FGID<\/jats:styled-content>\n patients with\n JHS<\/jats:styled-content>\n had increased chronic pain (23.2%\n vs<\/jats:italic>\n 11.9%,\n p<\/jats:italic>\n \u00a0=\u00a00.01), fibromyalgia (10.5%\n vs<\/jats:italic>\n 3.1%,\n p<\/jats:italic>\n \u00a0=\u00a00.01), somatization scores (13\n vs<\/jats:italic>\n 10,\n p<\/jats:italic>\n \u00a0<\u00a00.001), urinary autonomic scores (30.5\n vs<\/jats:italic>\n 20.7,\n p<\/jats:italic>\n \u00a0=\u00a00.03), and worse pain\u2010related\n QOL<\/jats:styled-content>\n scores (45.0\n vs<\/jats:italic>\n 63.5,\n p<\/jats:italic>\n \u00a0=\u00a00.004).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n \n JHS<\/jats:styled-content>\n is significantly associated with\n FGID<\/jats:styled-content>\n , and this subgroup of patients have increased comorbidity and decreased\n QOL<\/jats:styled-content>\n . Further research is required to understand the pathophysiological basis of this association.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.12535","type":"journal-article","created":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T15:22:00Z","timestamp":1427383320000},"page":"569-579","source":"Crossref","is-referenced-by-count":91,"title":["Functional gastrointestinal disorders are associated with the joint hypermobility syndrome in secondary care: a case\u2013control study"],"prefix":"10.1111","volume":"27","author":[{"given":"A.","family":"Fikree","sequence":"first","affiliation":[{"name":"Wingate Institute of Neurogastroenterology Centre for Digestive Diseases Blizard Institute of Cell and Molecular Science Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Aktar","sequence":"additional","affiliation":[{"name":"Wingate Institute of Neurogastroenterology Centre for Digestive Diseases Blizard Institute of Cell and Molecular Science Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Grahame","sequence":"additional","affiliation":[{"name":"Centre for Rheumatology Research University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Hakim","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Whipps Cross Hospital Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. K.","family":"Morris","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Preventive Medicine Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. H.","family":"Knowles","sequence":"additional","affiliation":[{"name":"Wingate Institute of Neurogastroenterology Centre for Digestive Diseases Blizard Institute of Cell and Molecular Science Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Aziz","sequence":"additional","affiliation":[{"name":"Wingate Institute of Neurogastroenterology Centre for Digestive Diseases Blizard Institute of Cell and Molecular Science Barts and the London School of Medicine and Dentistry Queen Mary University of London London 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