{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:38:22Z","timestamp":1765294702638,"version":"3.41.0"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Probiotics can be beneficial in irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>). Mosapride citrate, a selective 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>4<\/jats:sub>receptor agonist, stimulates gastrointestinal motility. We investigated the efficacy of combination therapy with probiotics and mosapride for non\u2010diarrheal\u2010type<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and eighty\u2010five<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>patients were randomly assigned to either a combination of probiotics (<jats:italic>Bacillus subtilis<\/jats:italic>and<jats:italic>Streptococcus faecium<\/jats:italic>) and mosapride at one of four different doses or a placebo for 4\u00a0weeks. The primary outcome was the proportion of patients experiencing adequate relief (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>) of global<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>symptoms at week 4. The secondary outcomes included subject's global assessment (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) of<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>symptom relief, individual symptoms, stool parameters, and<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The proportion of<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>at week 4 was significantly higher in all treatment groups compared to the placebo group (53.7% in group 1, 55.0% in group 2, 55.2% in group 3, 53.6% in group 4 [the highest dose], and 35.1% in placebo group, respectively,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The proportion of patients reporting \u2018completely or considerably relieved\u2019 in the<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>was higher in the treatment groups than in the placebo group. The abdominal pain\/discomfort score in the treatment group 4 was more prominently improved compared with that of the placebo group. In patients with constipation\u2010predominant<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>, the improvements in stool frequency and consistency were significantly higher in the treatment groups 4 and 1, respectively, than those in the placebo group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Combination therapy with probiotics and mosapride is effective for relief of symptoms in patients with non\u2010diarrheal\u2010type<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>. The study has been registered in the<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>National Library of Medicine (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>, NCT01505777).<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12544","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T07:29:44Z","timestamp":1427268584000},"page":"705-716","source":"Crossref","is-referenced-by-count":44,"title":["Efficacy of combination therapy with probiotics and mosapride in patients with<scp>IBS<\/scp>without diarrhea: a randomized, double\u2010blind, placebo\u2010controlled, multicenter, phase II trial"],"prefix":"10.1111","volume":"27","author":[{"given":"C. H.","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Chung\u2010Ang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Catholic University of Daegu School of Medicine Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Kyungpook National University School of Medicine Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010J.","family":"Myung","sequence":"additional","affiliation":[{"name":"University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. S.","family":"Park","sequence":"additional","affiliation":[{"name":"Keimyung University School of Medicine Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010I.","family":"Sohn","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.\u2010L.","family":"Rhee","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Ajou University School of Medicine Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. 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