{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:08:58Z","timestamp":1785157738769,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2013-261 and 2013-559"],"award-info":[{"award-number":["2013-261 and 2013-559"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biotechnology & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST)","award":["2011-0019632"],"award-info":[{"award-number":["2011-0019632"]}]},{"name":"Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea","award":["HI06C0868"],"award-info":[{"award-number":["HI06C0868"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The beneficial effect of biofeedback therapy (<jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content>) over a period of more than 2\u00a0years has not been studied in a large group of patients. The aim of this study was to evaluate the long\u2010term efficacy of <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content> for dyssynergic defecation (<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the results for 347 consecutive constipated patients with <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> who underwent <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content> for a median of five sessions between 2004 and 2009. Initial responses were assessed immediately after the completion of <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content>. A responder was defined as a subject with at least a three\u2010point improvement from before to after <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content> on an 11\u2010point global bowel satisfaction (<jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>) scale, or a two\u2010point improvement if the baseline <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> was more than six points. The probability of remaining a responder was estimated by non\u2010parametric maximum likelihood estimation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The initial response rate to <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content> was 72.3% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0251), Parkinson's disease and higher baseline <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> scores were associated with initial non\u2010response. The long\u2010term efficacy of <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content> was analyzed in 103 patients who were followed up for more than 6\u00a0months; the initial effects of <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content> were maintained in 85 of the patients (82.5%) during a median of 44\u00a0months of follow\u2010up (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\u00a0=\u00a012\u201368). The probability of remaining a responder was 60% at 2\u00a0years, and 58% at 5\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>The efficacy of <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content> is maintained for more than 2\u00a0years after <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content> in a considerable proportion of constipated patients with <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content> is effective and durable treatment for managing <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12552","type":"journal-article","created":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T08:53:40Z","timestamp":1427360020000},"page":"787-795","source":"Crossref","is-referenced-by-count":56,"title":["Long\u2010term efficacy of biofeedback therapy in patients with dyssynergic defecation: results of a median 44\u00a0months follow\u2010up"],"prefix":"10.1111","volume":"27","author":[{"given":"H. J.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Asan Digestive Disease Research Institute Asan Medical Center University of Ulsan College of Medicine Seoul Korea"},{"name":"Health Screening and Promotion Center Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010J.","family":"Boo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jeju National University School of Medicine Jeju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. W.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Digestive Disease Research Institute Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Y.","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Digestive Disease Research Institute Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. S.","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Digestive Disease Research Institute Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. J.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Digestive Disease Research Institute Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Digestive Disease Research Institute Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.\u2010H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Digestive Disease Research Institute Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u2010J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Digestive Disease Research Institute Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. D.","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Digestive Disease Research Institute Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010S.","family":"Byeon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Digestive Disease Research Institute Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010K.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Digestive Disease Research Institute Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Digestive Disease Research Institute Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010J.","family":"Myung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Digestive Disease Research Institute Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.164"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2008.06.011"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2011.01.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9486-5"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjm.2013.84.1.49"},{"key":"e_1_2_11_7_1","first-page":"1471","article-title":"Audit of constipation in a tertiary referral gastroenterology practice","volume":"90","author":"Surrenti E","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-375000-6.00062-8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.10.028"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.12.023"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0814-9"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.014"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12158"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2013.7.2.157"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2010.483741"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.53"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410009348"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1997.02746.x"},{"key":"e_1_2_11_19_1","first-page":"56","article-title":"Response to biofeedback therapy for patients with rectal hyposensitivity","volume":"6","author":"Jung KW","year":"2008","journal-title":"Intest Res"},{"key":"e_1_2_11_20_1","first-page":"289","article-title":"[Clinical factors associated with response to biofeedback therapy for patients with chronic constipation]","volume":"42","author":"Park DH","year":"2003","journal-title":"Korean J Gastroenterol"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236637"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.7.1060"},{"key":"e_1_2_11_23_1","first-page":"337","article-title":"Clinical usefulness of KolomarkTM, a Korean radio\u2010opaque marker for measuring colon transit time","volume":"60","author":"Kim JE","year":"2001","journal-title":"Korean J Med"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00526.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00950.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.247"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.10.044"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90837-7"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2003.18.3.181"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2013.19.4.532"},{"key":"e_1_2_11_31_1","first-page":"48","volume-title":"The Statistical Analysis of Interval\u2010Censored Failure Time Data, Chapter 3","author":"Jianguo S","year":"2006"},{"key":"e_1_2_11_32_1","unstructured":"TherneauT.A Package for Survival Analysis in S. R package version 2.37\u20104.2013. Available at:http:\/\/CRAN.R-project.org\/package=survival"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02554946"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01345.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.4.517"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-003-0010-0"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199915030-00004"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04653.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2010.16.2.177"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2013.19.2.149"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12552","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:40:21Z","timestamp":1696225221000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,25]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/nmo.12552"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12552","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,25]]}}}