{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T22:56:25Z","timestamp":1770677785189,"version":"3.49.0"},"reference-count":62,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T00:00:00Z","timestamp":1427673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Previous studies summarized altered brain functional patterns in functional dyspepsia (FD<\/jats:styled-content>) patients, but how the brain structural patterns are related to FD<\/jats:styled-content> remains largely unclear. The objective of this study was to determine the brain structural characteristics in FD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Optimized voxel\u2010based morphometry and tract\u2010based spatial statistics were employed to investigate the changes in gray matter (GM<\/jats:styled-content>) and white matter (WM<\/jats:styled-content>) respectively in 34 FD<\/jats:styled-content> patients with postprandial distress syndrome and 33 healthy controls based on T1\u2010weighted and diffusion\u2010weighted imaging. The Pearson's correlation evaluated the link among GM<\/jats:styled-content> alterations, WM<\/jats:styled-content> abnormalities, and clinical variables in FD<\/jats:styled-content> patients. The optimal brain structural parameters for identifying FD<\/jats:styled-content> were explored using the receiver operating characteristic curve.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Compared to controls, FD<\/jats:styled-content> patients exhibited a decrease in GM<\/jats:styled-content> density (GMD<\/jats:styled-content>) in the right posterior insula\/temporal superior cortex (marked as pINS<\/jats:styled-content>), right inferior frontal cortex (IFC<\/jats:styled-content>), and left middle cingulate cortex, and an increase in fractional anisotropy (FA<\/jats:styled-content>) in the posterior limb of the internal capsule, posterior thalamic radiation, and external capsule (EC<\/jats:styled-content>). Interestingly, the GMD<\/jats:styled-content> in the pINS<\/jats:styled-content> was significantly associated with GMD<\/jats:styled-content> in the IFC<\/jats:styled-content> and FA<\/jats:styled-content> in the EC<\/jats:styled-content>. Moreover, the EC<\/jats:styled-content> adjacent to the pINS<\/jats:styled-content> provided the best performance for distinguishing FD<\/jats:styled-content> patients from controls.<\/jats:p><\/jats:sec>Conclusions & Inferences<\/jats:title>Our results showed pINS<\/jats:styled-content>\u2010related structural abnormalities in FD<\/jats:styled-content> patients, indicating that GM<\/jats:styled-content> and WM<\/jats:styled-content> parameters were not affected independently. These findings would lay the foundation for probing an efficient target in the brain for treating FD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12560","type":"journal-article","created":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T21:31:59Z","timestamp":1427837519000},"page":"856-864","source":"Crossref","is-referenced-by-count":13,"title":["Anatomically related gray and white matter alterations in the brains of functional dyspepsia patients"],"prefix":"10.1111","volume":"27","author":[{"given":"J.","family":"Nan","sequence":"first","affiliation":[{"name":"School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mu","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging First Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology Xidian University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Liang","sequence":"additional","affiliation":[{"name":"The 3rd Teaching Hospital Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Zeng","sequence":"additional","affiliation":[{"name":"The 3rd Teaching Hospital Chengdu University of Traditional Chinese Medicine Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,30]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"237","article-title":"Rome III: new standard for functional gastrointestinal disorders","volume":"15","author":"Drossman DA","year":"2006","journal-title":"J Gastrointest Liver"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.04.015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.39"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065870"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12311"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-012309-103958"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.02.018"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.07.053"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2003.93"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01304.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.12.014"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.10"},{"key":"e_1_2_10_14_1","first-page":"1445","article-title":"Diffusion\u2010tensor MR imaging of gray and white matter development during normal human brain maturation","volume":"23","author":"Mukherjee P","year":"2002","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12372"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068383"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.405"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00445.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3173"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(71)71479-0"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01730060026004"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm184"},{"key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel\u2010based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"Good CD","year":"2002","journal-title":"NeuroImage"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.02.007"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-842X.00156"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.060"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1058"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.09.088"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.02.024"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.148.3.6878708"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2005.04.005"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2012.06.001"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn894"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00228.x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0296-3"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.68903.x"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.03.049"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.09.024"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01666.x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.10.026"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.175000"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg065"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.05958.x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i25.3438"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00467-5"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.034"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.03.023"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.01.037"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.08.005"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219562110"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.12.035"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2301021640"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2010.04.013"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2004.09.002"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(03)00096-5"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00060"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.25.032502.111311"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12017"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.043"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12067"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12560","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:39:40Z","timestamp":1696225180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,30]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/nmo.12560"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12560","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,30]]}}}