{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:56:21Z","timestamp":1790517381374,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T00:00:00Z","timestamp":1430352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psychological factors are associated with functional gastrointestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) disorders. Literature suggests that somatization is associated with functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>). However, the relationship between organic dyspepsia (<jats:styled-content style=\"fixed-case\">OD<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> subtypes and somatization is poorly described. We aimed to examine this issue in a cross\u2010sectional study of secondary care patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographic and <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> symptom data were collected from 4224 adult patients via the Rome III questionnaire. Somatization data were collected using the patient health questionnaire\u201012. Mean somatization score and number of somatic symptoms were compared between patients with organic and <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>, and between <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> subtypes using analysis of variance. The same comparison was undertaken for the proportion of patients reporting individual somatic symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Exactly, 783 patients met criteria for dyspepsia, of whom 231 (29.5%) had organic disease following upper <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> endoscopy. Mean somatization scores and number of somatic symptoms were no higher in functional <jats:italic>vs <\/jats:italic><jats:styled-content style=\"fixed-case\">OD<\/jats:styled-content> (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.23; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.19). In addition, while the prevalence of somatization in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> was relatively high, there was no difference in severity of somatization in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Somatization is associated with functional and <jats:styled-content style=\"fixed-case\">OD<\/jats:styled-content> to the same degree. Overall severity of somatization did not appear to vary according to <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> subtype.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12578","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T09:41:38Z","timestamp":1430386898000},"page":"1024-1031","source":"Crossref","is-referenced-by-count":24,"title":["No increase in prevalence of somatization in functional <i>vs<\/i> organic dyspepsia: a cross\u2010sectional survey"],"prefix":"10.1111","volume":"27","author":[{"given":"D. J.","family":"Gracie","sequence":"first","affiliation":[{"name":"Leeds Gastroenterology Institute St. James's University Hospital Leeds UK"},{"name":"Leeds Institute of Biomedical and Clinical Sciences University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bercik","sequence":"additional","affiliation":[{"name":"Farncombe Family Digestive Health Research Institute Gastroenterology Division McMaster University Health Sciences Center Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. G.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Gastroenterology Department St. Joseph's Healthcare Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bolino","sequence":"additional","affiliation":[{"name":"Farncombe Family Digestive Health Research Institute Gastroenterology Division McMaster University Health Sciences Center Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. I.","family":"Pintos\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Farncombe Family Digestive Health Research Institute Gastroenterology Division McMaster University Health Sciences Center Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Moayyedi","sequence":"additional","affiliation":[{"name":"Farncombe Family Digestive Health Research Institute Gastroenterology Division McMaster University Health Sciences Center Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Ford","sequence":"additional","affiliation":[{"name":"Leeds Gastroenterology Institute St. James's University Hospital Leeds UK"},{"name":"Leeds Institute of Biomedical and Clinical Sciences University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102014\u2010307843"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04270.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0269-2813.2004.01807.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.03.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.014"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.05.031"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14080"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06633.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02845.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.08.026"},{"issue":"1","key":"e_1_2_11_13_1","first-page":"S50","article-title":"A randomized, double\u2010blind, placebo\u2010controlled trial of low dose imipramine for treatment of refractory functional dyspepsia","volume":"140","author":"Wu JCCP","year":"2011","journal-title":"Gastroenterology"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03277.x"},{"key":"e_1_2_11_15_1","volume-title":"The ICD 10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research","year":"1993"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.43.1.1"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2006.01.021"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13074"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12396"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00245-4"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.328"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.158162"},{"key":"e_1_2_11_23_1","first-page":"71","article-title":"Psychological factors in patients with peptic ulcerand functional dyspepsia","volume":"5","author":"Faramarzi M","year":"2014","journal-title":"Caspian journal of internal medicine"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.048"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12573"},{"key":"e_1_2_11_26_1","first-page":"835","volume-title":"Rome III: The Functional Gastrointestinal Disorders","author":"Whitehead WE","year":"2006"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.18.1737"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.106580"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1990.00040031685016"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04402.x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200203000-00008"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12608"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12578","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T12:50:43Z","timestamp":1696251043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,30]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/nmo.12578"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12578","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,30]]}}}