{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:15:39Z","timestamp":1789193739470,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T00:00:00Z","timestamp":1430697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rectal disorders during ulcerative colitis (<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>) drastically alter the quality of life and may result from an impairment of rectal perception and compliance. This study aims to assess anorectal disorders in patients with mild\u2010to\u2010moderate <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Anal pressures and the rectal responses to phasic rectal isobaric distension in 10 patients with mild\u2010to\u2010moderate <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> were prospectively compared with those in 10 healthy volunteers (<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The patients in each group were similar regarding age, gender, and delivery. In the resting state, the anal canal pressures were similar between the groups. Only the squeeze pressures of the lower anal canal were significantly lower in <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> patients than in <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>s. During phasic isobaric distension, rectal sensitivity was similar between the groups, whatever the step of distension. Isobaric rectal distension resulted in a significant decrease of the rectoanal inhibitory reflex and a decrease in rectal tone and a significant drop in rectal compliance in <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> patients compared with <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Patients showing mild\u2010to\u2010moderate <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> experience rectal compliance and innervation disorders without a significant change in rectal sensitivity. The findings of this work suggest impairment not only of the properties of the rectal wall but also of intrinsic innervation. Repeated evaluation over time may be helpful for analyzing the reversibility of the process after healing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12580","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T01:32:53Z","timestamp":1430789573000},"page":"1032-1037","source":"Crossref","is-referenced-by-count":19,"title":["Anorectal dysfunction in patients with ulcerative colitis: impaired adaptation or enhanced perception?"],"prefix":"10.1111","volume":"27","author":[{"given":"C.","family":"Brochard","sequence":"first","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"},{"name":"Services d'Explorations Fonctionnelles Digestives CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"},{"name":"INSERM U991 Universit\u00e9 de Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Siproudhis","sequence":"additional","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"},{"name":"INSERM U991 Universit\u00e9 de Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ropert","sequence":"additional","affiliation":[{"name":"Services d'Explorations Fonctionnelles Digestives CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mallak","sequence":"additional","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u2010F","family":"Bretagne","sequence":"additional","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bouguen","sequence":"additional","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"},{"name":"INSERM U991 Universit\u00e9 de Rennes Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.6.769"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.03.023"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.19.1.64"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90255-1"},{"key":"e_1_2_8_6_1","first-page":"892","article-title":"Anorectal manometry in active and quiescent ulcerative colitis","volume":"84","author":"Loening\u2010Baucke V","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018885028501"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00496148"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5375.89"},{"key":"e_1_2_8_10_1","first-page":"347","article-title":"A multifunction and programmable computerized barostat","volume":"17","author":"Hachet T","year":"1993","journal-title":"Gastroent\u00e9rologie Clin Biol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12256"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00912.x"},{"issue":"2","key":"e_1_2_8_13_1","first-page":"G280","article-title":"Reflex changes in intestinal tone: relationship to perception","volume":"261","author":"Rouillon JM","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.579156"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.4.497"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1740925X11000068"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01146.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00361.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e3182a2952b"}],"container-title":["Neurogastroenterology &amp; 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