{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:56:27Z","timestamp":1790517387745,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T00:00:00Z","timestamp":1438041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"KULeuven","award":["Methusalem"],"award-info":[{"award-number":["Methusalem"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The Rome III consensus proposed to subdivide functional dyspepsia (\n FD<\/jats:styled-content>\n ) into two groups: meal\u2010related dyspepsia or postprandial distress syndrome (\n PDS<\/jats:styled-content>\n ), and meal\u2010unrelated dyspepsia or epigastric pain syndrome (\n EPS<\/jats:styled-content>\n ). However, in clinical practice, overlap between both has been reported to be as high as 50%, thereby hampering clinical applicability. Although\n EPS<\/jats:styled-content>\n is referred to as meal\u2010unrelated dyspepsia, relationship of symptoms to meal ingestion in this category is not formally addressed in the Rome III criteria. The aim of our study was to investigate whether taking into account the relationship of epigastric pain and nausea to meal ingestion may help to improve separation between\n EPS<\/jats:styled-content>\n and\n PDS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Consecutive ambulatory tertiary\u2010care patients with epigastric symptoms filled out Rome III gastro\u2010duodenal questionnaires with supplementary questions. Those fulfilling Rome III\n FD<\/jats:styled-content>\n criteria and a negative endoscopy were identified and subdivided into \u2018pure\u2019\n PDS<\/jats:styled-content>\n patients (i.e., meeting criteria for\n PDS<\/jats:styled-content>\n without\n EPS<\/jats:styled-content>\n symptoms), \u2018pure\u2019\n EPS<\/jats:styled-content>\n (i.e., meeting criteria for\n EPS<\/jats:styled-content>\n without\n PDS<\/jats:styled-content>\n symptoms), and overlapping\n PDS<\/jats:styled-content>\n \u2010\n EPS<\/jats:styled-content>\n (i.e., symptoms of both\n PDS<\/jats:styled-content>\n and\n EPS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n Out of 1029 patients coming to endoscopy, 199 patients (73% females, 45.9\u00a0\u00b1\u00a01.0\u00a0years,\n BMI<\/jats:styled-content>\n : 23.7\u00a0\u00b1\u00a00.35) fulfilled Rome III\n FD<\/jats:styled-content>\n diagnostic criteria, and could be subdivided into pure\n PDS<\/jats:styled-content>\n (69% females, 49\u00a0\u00b1\u00a02\u00a0years,\n BMI<\/jats:styled-content>\n : 24.2\u00a0\u00b1\u00a00.61), pure\n EPS<\/jats:styled-content>\n (59% females, 47.4\u00a0\u00b1\u00a02\u00a0years,\n BMI<\/jats:styled-content>\n : 23.2\u00a0\u00b1\u00a00.97) and overlapping\n PDS<\/jats:styled-content>\n \u2010\n EPS<\/jats:styled-content>\n (64% females, age 43\u00a0\u00b1\u00a05\u00a0years,\n BMI<\/jats:styled-content>\n : 26\u00a0\u00b1\u00a00.46). Compared with pure\n EPS<\/jats:styled-content>\n patients, the overlap\n PDS<\/jats:styled-content>\n \u2010\n EPS<\/jats:styled-content>\n patients were characterized by a higher occurrence of postprandial epigastric pain (70%\n vs<\/jats:italic>\n 31%,\n p<\/jats:italic>\n \u00a0<\u00a00.0001), while the occurrence of epigastric pain in between meals was borderline (48%\n vs<\/jats:italic>\n 38%,\n p<\/jats:italic>\n \u00a0=\u00a00.05). In addition, the overlap\n PDS<\/jats:styled-content>\n \u2010\n EPS<\/jats:styled-content>\n patients reported a higher occurrence of postprandial nausea (23%\n vs<\/jats:italic>\n 0%,\n p<\/jats:italic>\n \u00a0<\u00a00.0001), and bloating (79%\n vs<\/jats:italic>\n 28%,\n p<\/jats:italic>\n \u00a0=\u00a00.0001). When postprandial epigastric pain and postprandial nausea were considered as\n PDS<\/jats:styled-content>\n symptoms, the \u2018adapted\u2019 subdivision identified 48% pure\n PDS<\/jats:styled-content>\n , 16% pure\n EPS<\/jats:styled-content>\n , and 36% overlapping\n PDS<\/jats:styled-content>\n \u2010\n EPS<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n \n EPS<\/jats:styled-content>\n and\n PDS<\/jats:styled-content>\n symptoms frequently coexist in\n FD<\/jats:styled-content>\n patients, with postprandial symptoms substantially contributing to the overlap. A more rigorous linking of postprandially occurring symptoms to\n PDS<\/jats:styled-content>\n , regardless of their qualitative nature, may improve the separation between\n PDS<\/jats:styled-content>\n and\n EPS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.12585","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T20:48:10Z","timestamp":1438116490000},"page":"1069-1074","source":"Crossref","is-referenced-by-count":60,"title":["Rome III functional dyspepsia subdivision in\n PDS<\/scp>\n and\n EPS<\/scp>\n : recognizing postprandial symptoms reduces overlap"],"prefix":"10.1111","volume":"27","author":[{"given":"F.","family":"Carbone","sequence":"first","affiliation":[{"name":"Translational Research Centre for Gastrointestinal Disorders University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Holvoet","sequence":"additional","affiliation":[{"name":"Translational Research Centre for Gastrointestinal Disorders University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tack","sequence":"additional","affiliation":[{"name":"Translational Research Centre for Gastrointestinal Disorders University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01262.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-301986"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000156109.97999.d1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.14"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S1590-8658(04)00082-9","article-title":"Visceral hypersensitivity in functional disorders of the upper gastrointestinal tract","volume":"36","author":"Sarnelli G","year":"2004","journal-title":"Dig Liver Dis"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000007856.71462.6c"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357854"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000121347"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01381.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.03.039"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.057"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01859.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01939.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.77244"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-8-43"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(08)62926-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12348"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006051204000511"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31815591f7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.137125"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.018"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12227"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655201750422611"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12381"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1993.tb00073.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.053355"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00454-9"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2003.00431.x"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12585","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:20:30Z","timestamp":1695496830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,28]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/nmo.12585"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12585","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725689027.793536943","asserted-by":"object"}]},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,28]]}}}