{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T14:42:21Z","timestamp":1766155341687},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T00:00:00Z","timestamp":1431388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adult studies indicate a role for ghrelin in functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>) mediated through ghrelin's effect on gastric emptying (<jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>). This study examines the relationship between ghrelin, liquid <jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>, and pain in children with <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients reporting symptoms consistent with post\u2010prandial distress syndrome (<jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content>) and 17 healthy controls were enrolled. All participants received a liquid meal containing <jats:sup>13<\/jats:sup>C\u2010sodium acetate. Pain severity, liquid <jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content> utilizing exhaled <jats:sup>13<\/jats:sup>CO<jats:sub>2<\/jats:sub> from the sodium acetate breath tests (<jats:styled-content style=\"fixed-case\">ABT<\/jats:styled-content>), plasma acyl ghrelin (<jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>), and des\u2010acyl ghrelin concentrations were measured at specific intervals over 240\u00a0min following ingestion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content> patients demonstrated lower mean baseline <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content> (14.8\u00a0\u00b1\u00a09.7 <jats:italic>vs<\/jats:italic> 27.2\u00a0\u00b1\u00a014.0\u00a0fmol\/mL; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.013), <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content> C<jats:sub>max<\/jats:sub> (24.6\u00a0\u00b1\u00a08.2 <jats:italic>vs<\/jats:italic> 40.5\u00a0\u00b1\u00a016.8\u00a0fmol\/mL; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007), and <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content> flux (18.2\u00a0\u00b1\u00a07.8 <jats:italic>vs<\/jats:italic> 32.7\u00a0\u00b1\u00a017.3\u00a0fmol\/mL; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.015) than controls. The time to reach maximum exhaled <jats:sup>13<\/jats:sup>CO<jats:sub>2<\/jats:sub> concentration (T <jats:sub>max<\/jats:sub>) was longer in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients than controls (47.5\u00a0\u00b1\u00a018.5 vs 35.8\u00a0\u00b1\u00a011.8\u00a0min; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.046). Significant relationships between ghrelin analyte ratios and <jats:styled-content style=\"fixed-case\">ABT<\/jats:styled-content> parameters were largely confined to control participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content> in children is associated with lower fasting and maximum <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content> concentrations, and dampened <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content> flux. These data suggest a possible role for altered ghrelin physiology in the pathogenesis of <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12591","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T09:58:50Z","timestamp":1431424730000},"page":"1120-1126","source":"Crossref","is-referenced-by-count":10,"title":["Plasma ghrelin and liquid gastric emptying in children with functional dyspepsia consistent with post\u2010prandial distress syndrome"],"prefix":"10.1111","volume":"27","author":[{"given":"N. M.","family":"Hijaz","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Children's Mercy Kansas City Kansas City MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Friesen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Children's Mercy Kansas City Kansas City MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. V.","family":"Schurman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Children's Mercy Kansas City Kansas City MO USA"},{"name":"Division of Developmental &amp; Behavioral Sciences Children's Mercy Kansas City Kansas City MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation Children's Mercy Kansas City Kansas City MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Abdel\u2010Rahman","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation Children's Mercy Kansas City Kansas City MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1847-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181d1363c"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v5.i3.122"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005493123557"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12205"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2013.7.5.505"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1800273"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01362.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2005.83"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0456"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510015403"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000225614.94470.47"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.00032.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000215389"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i18.2231"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000205740"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12348"},{"key":"e_1_2_10_20_1","first-page":"62","article-title":"Rikkunshito improves the symptoms in patients with functional dyspepsia, accompanied by an increase in the level of plasma ghrelin","volume":"59","author":"Arai M","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.10.005"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/3\/4\/047004"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-13-0391"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.18433\/J3GP53"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01239.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-381272-8.00021-0"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2014.09.015"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.04.019"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2010.07.010"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v4.i4.86"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12591","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:21:08Z","timestamp":1695511268000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,12]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/nmo.12591"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12591","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,12]]}}}