{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:19:53Z","timestamp":1781738393661,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T00:00:00Z","timestamp":1434672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Many patients complain of abdominal symptoms with dairy products; however, clinical and psychosocial factors associated with self\u2010reported lactose intolerance (<jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content>) have not been assessed in large studies. In particular, data are lacking from lactase deficient populations. This prospective cohort study assessed the prevalence of, and risk factors for, <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content> in Chinese patients attending a gastroenterology clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients completed questionnaires to assess digestive health (Rome III), psychological state (<jats:styled-content style=\"fixed-case\">HADS<\/jats:styled-content>), life event stress (<jats:styled-content style=\"fixed-case\">LES<\/jats:styled-content>), food intake, and quality\u2010of\u2010life (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u20108). A representative sample completed genetic studies and hydrogen breath testing (<jats:styled-content style=\"fixed-case\">HBT<\/jats:styled-content>) at the clinically relevant dose of 20\u00a0g lactose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content> was present in 411\/910 (45%) clinic patients with functional abdominal symptoms. The genotype in all subjects was C\/C\u201013910. A small number of novel <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in lactase promoter region were identified, including C\/T\u201013908 which appeared to confer lactase persistence. Over half of the patients (54%) completed the 20\u00a0g lactose <jats:styled-content style=\"fixed-case\">HBT<\/jats:styled-content> with 58% (285\/492) reporting typical symptoms. Positive and negative predictive values of <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content> for abdominal symptoms during <jats:styled-content style=\"fixed-case\">HBT<\/jats:styled-content> were 60% and 44%, respectively. Psychological state and stress were not associated with <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content> in clinic patients. <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content> impacted on physical quality\u2010of\u2010life and was associated with reduced ingestion of dairy products, legumes, and dried fruit (<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>In a lactase deficient population, approximately half of patients attending clinic with functional gastrointestinal symptoms reported intolerance to dairy products; however, <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content> did not predict findings on 20\u00a0g lactose <jats:styled-content style=\"fixed-case\">HBT<\/jats:styled-content>. Independent of psychosocial factors, <jats:styled-content style=\"fixed-case\">SLI<\/jats:styled-content> impacted on quality\u2010of\u2010life and impacted on food choices with restrictions not limited to dairy products.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12602","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T10:17:14Z","timestamp":1434709034000},"page":"1138-1146","source":"Crossref","is-referenced-by-count":67,"title":["Self\u2010reported lactose intolerance in clinic patients with functional gastrointestinal symptoms: prevalence, risk factors, and impact on food choices"],"prefix":"10.1111","volume":"27","author":[{"given":"X.","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Pohl","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology University Hospital Z\u00fcrich Z\u00fcrich Switzerland"},{"name":"Z\u00fcrich Centre for Integrative Human Physiology (ZIHP) University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fried","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology University Hospital Z\u00fcrich Z\u00fcrich Switzerland"},{"name":"Z\u00fcrich Centre for Integrative Human Physiology (ZIHP) University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fox","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology University Hospital Z\u00fcrich Z\u00fcrich Switzerland"},{"name":"Z\u00fcrich Centre for Integrative Human Physiology (ZIHP) University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03557.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640613484463"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510001297"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-9-82"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.11.034"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/64.2.197"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507063330101"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.03.027"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcq082"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-12-201006150-00248"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.198"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04252.x"},{"key":"e_1_2_11_14_1","first-page":"51","article-title":"Clinical ramifications of malabsorption of fructose and other short\u2010chain carbohydrates","volume":"1","author":"Barrett J","year":"2007","journal-title":"Pract Gastroenterol"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.105"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802588117"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.0301207"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.009860"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(67)90010-4"},{"key":"e_1_2_11_20_1","volume-title":"Food Composition Table in China (second volume)","author":"Yuexin Y","year":"2004"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00973.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1946"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng826"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00086-8"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5359.37045"},{"key":"e_1_2_11_26_1","unstructured":"RohrerF.China drinks its milk BBC News Magazine[serial online] 2007. Available at:http:\/\/news.bbc.co.uk\/2\/hi\/uk_news\/magazine\/6934709.stm(accessed 7 August 2007)."},{"key":"e_1_2_11_27_1","first-page":"1129","article-title":"The prevalence of lactase deficiency and lactose intolerance in Chinese children of different ages","volume":"113","author":"Yang Y","year":"2000","journal-title":"Chin Med J"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.040048"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200503000-00018"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510015764"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2007001100004"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2007.04.028"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-006-0291-1"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01936.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0210-5705(12)70029-8"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2011.03.016"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06133.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06149.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.058"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2005.07.002"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655200451162"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200103000-00001"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2006.07.010"},{"key":"e_1_2_11_44_1","first-page":"92","article-title":"Dietary fructose intolerance: diet modification can impact self\u2010rated health and symptom control","volume":"7","author":"Johlin FC","year":"2004","journal-title":"Nutr Clin Care"},{"key":"e_1_2_11_45_1","first-page":"583","article-title":"Carbohydrate malabsorption and the effect of dietary restriction on symptoms of irritable bowel syndrome and functional bowel complaints","volume":"2","author":"Goldstein R","year":"2000","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37095"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12602","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:21:00Z","timestamp":1695511260000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,19]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/nmo.12602"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12602","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,19]]}}}