{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T15:16:28Z","timestamp":1722093388049},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,6,14]],"date-time":"2015-06-14T00:00:00Z","timestamp":1434240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Catechol\u2010O\u2010methyl transferase (<jats:styled-content style=\"fixed-case\">COMT<\/jats:styled-content>) and brain\u2010derived neurotrophic factor (<jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content>) are neuro\u2010modulatory proteins that have been demonstrated to affect cortical plasticity, which in turn has been shown to affect age\u2010related changes and neuronal functioning in humans. Here, we tested the hypothesis that single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>) within <jats:styled-content style=\"fixed-case\">COMT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> genes are associated with dysphagia in older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 800 community\u2010dwelling older individuals were sent the Sydney Oropharyngeal Dysphagia Questionnaire to identify swallowing difficulties. <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> from this population was available for study and used to genotype 18 <jats:styled-content style=\"fixed-case\">COMT<\/jats:styled-content> and 12 <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> polymorphisms. Logistic regression statistical models were used to identify potential associations between dysphagia and the genotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>A total of 638 individuals completed the questionnaire, giving an 80% response rate. Of these, 538 were genotyped for <jats:styled-content style=\"fixed-case\">COMT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> polymorphisms. Age was found to predict dysphagia (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.018, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.08, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.01\u20131.14). The <jats:styled-content style=\"fixed-case\">COMT<\/jats:styled-content> polymorphism <jats:italic><jats:bold>rs165599<\/jats:bold><\/jats:italic> and the <jats:styled-content style=\"fixed-case\">BDNF<\/jats:styled-content> polymorphism <jats:italic><jats:bold>rs10835211<\/jats:bold><\/jats:italic> were found to predict dysphagia and have an interactive effect (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.028), which varied according to the carrier status of the other. In the case of <jats:styled-content style=\"fixed-case\">SNP <\/jats:styled-content><jats:italic><jats:bold>rs10835211<\/jats:bold><\/jats:italic>, the effect of heterozygosity was protective or harmful dependent on the respective status of <jats:italic><jats:bold>rs165599<\/jats:bold><\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>These results suggest that certain interactions between plasticity genes contribute to the development of dysphagia with increasing age. This highlights a possible role for genetic factors in future monitoring and treating individuals affected by dysphagia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12609","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T01:06:58Z","timestamp":1434330418000},"page":"1223-1231","source":"Crossref","is-referenced-by-count":8,"title":["A novel association between <scp>COMT<\/scp> and <scp>BDNF<\/scp> gene polymorphisms and likelihood of symptomatic dysphagia in older people"],"prefix":"10.1111","volume":"27","author":[{"given":"D.","family":"Nimmons","sequence":"first","affiliation":[{"name":"Centre for Gastrointestinal Sciences Institute of Inflammation and Repair University of Manchester Manchester UK"},{"name":"Salford Royal NHS Foundation Trust Salford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Pendleton","sequence":"additional","affiliation":[{"name":"Salford Royal NHS Foundation Trust Salford UK"},{"name":"Centre for Clinical and Cognitive Neuroscience Institute of Brain, Behaviour and Mental Health University of Manchester Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Payton","sequence":"additional","affiliation":[{"name":"Salford Royal NHS Foundation Trust Salford UK"},{"name":"Centre for Integrated Genomic Medical Research UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Ollier","sequence":"additional","affiliation":[{"name":"Salford Royal NHS Foundation Trust Salford UK"},{"name":"Centre for Integrated Genomic Medical Research UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Horan","sequence":"additional","affiliation":[{"name":"Manchester Medical School University of Manchester Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Salford Royal NHS Foundation Trust Salford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Centre for Gastrointestinal Sciences Institute of Inflammation and Repair University of Manchester Manchester UK"},{"name":"Salford Royal NHS Foundation Trust Salford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6726.721"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1809"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(92)90316-K"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-1047(91)90439-W"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2007.00020.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300703"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.8.2714"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540050026010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2004.09.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.12.1.12"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1379.018"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.120.2.272"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1176\/ajp.157.4.635","article-title":"Age\u2010related cognitive deficits mediated by changes in the striatal dopamine system","volume":"157","author":"B\u00e4ckman L","year":"2000","journal-title":"Am J Psychiatry"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.05.023"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:BEGE.0000038491.06972.8c"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1162\/0898929054475136"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.09.001.2008"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.07.009"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1310\/tsr1604-282"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00035-7"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0786"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(03)00118-0"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.11.067"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.05.047"},{"key":"e_1_2_10_26_1","unstructured":"2010 Taylor & Francis Group San Diego CA PMA Rabbitt L McInnes P Diggle F Holland N Bent V Abson N Pendleton M. 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