{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:10:17Z","timestamp":1781244617791,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK079902"],"award-info":[{"award-number":["R01DK079902"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      We assessed whether a high\u2010resolution impedance manometry (\n                      <jats:styled-content style=\"fixed-case\">HRIM<\/jats:styled-content>\n                      ) metric, bolus flow time (\n                      <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content>\n                      ) across the esophagogastric junction (\n                      <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content>\n                      ), was abnormal in achalasia patients subtyped by the Chicago Classification and compared\n                      <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content>\n                      to other\n                      <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content>\n                      metrics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">HRIM<\/jats:styled-content>\n                      studies were performed in 60 achalasia patients (14 type I, 36 type II and 10 type III) and 15 healthy controls. Studies were analyzed with a\n                      <jats:styled-content style=\"fixed-case\">MATLAB<\/jats:styled-content>\n                      program to calculate\n                      <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content>\n                      using a virtual\n                      <jats:styled-content style=\"fixed-case\">HRIM<\/jats:styled-content>\n                      sleeve. Integrated relaxation pressure (\n                      <jats:styled-content style=\"fixed-case\">IRP<\/jats:styled-content>\n                      ) and basal end\u2010expiratory\n                      <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content>\n                      pressure were also calculated. The relationship between\n                      <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content>\n                      and dysphagia symptom scores was assessed using the impaction dysphagia questionnaire (\n                      <jats:styled-content style=\"fixed-case\">IDQ<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Median\n                      <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content>\n                      was significantly lower in achalasia patients (0.5\u00a0s, range 0.0\u20133.5\u00a0s) compared to controls (3.5\u00a0s, range 2.0\u20135.0\u00a0s;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                      <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content>\n                      was significantly lower in types I and II than in type III achalasia in both the supine and upright positions (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001).\n                      <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content>\n                      was the only\n                      <jats:styled-content style=\"fixed-case\">HRIM<\/jats:styled-content>\n                      metric significantly associated with\n                      <jats:styled-content style=\"fixed-case\">IDQ<\/jats:styled-content>\n                      score in both the supine (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.20,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0046) and upright positions (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content>\n                      <\/jats:italic>\n                      was significantly reduced in all subtypes of achalasia and complementary to the\n                      <jats:styled-content style=\"fixed-case\">IRP<\/jats:styled-content>\n                      as a diagnostic discriminant in equivocal achalasia cases. Additionally,\n                      <jats:styled-content style=\"fixed-case\">BFT<\/jats:styled-content>\n                      had a more robust correlation with dysphagia severity compared to other metrics of\n                      <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content>\n                      function.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12613","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T23:10:13Z","timestamp":1434669013000},"page":"1232-1238","source":"Crossref","is-referenced-by-count":49,"title":["High\u2010resolution impedance manometry measurement of bolus flow time in achalasia and its correlation with dysphagia"],"prefix":"10.1111","volume":"27","author":[{"given":"Z.","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Medicine Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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J.","family":"Kahrilas","sequence":"additional","affiliation":[{"name":"Department of Medicine Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"Ciolino","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Pandolfino","sequence":"additional","affiliation":[{"name":"Department of Medicine Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,18]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"G1098","article-title":"Topography of normal and high\u2010amplitude esophageal peristalsis","volume":"265","author":"Clouse RE","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01952.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01634.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.05.026"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00011.2005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12308"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.03.058"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00119.2014"},{"key":"e_1_2_10_11_1","first-page":"G251","article-title":"Sleeve device functions as a Starling resistor to record sphincter pressure","volume":"248","author":"Linehan JH","year":"1985","journal-title":"Am J Physiol"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.05323.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00252.2007"},{"issue":"1","key":"e_1_2_10_14_1","first-page":"S","article-title":"Improving the Integrated Relaxation Pressure (IRP) cutoff value for the diagnosis of achalasia using a classification and regression tree (CART) model","volume":"142","author":"Lin Z","year":"2012","journal-title":"Gastroenterology"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00589.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00148.2014"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01578.x"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12613","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:49:19Z","timestamp":1695491359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,18]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/nmo.12613"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12613","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725571630.793508848","asserted-by":"object"}]},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,18]]}}}