{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:12:52Z","timestamp":1786547572135,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T00:00:00Z","timestamp":1440460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"This research was funded by Health Labour Sciences Research Grant.","award":["23-2"],"award-info":[{"award-number":["23-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Impaired gastric accommodation is one of the major features of functional dyspepsia. Mosapride citrate is a 5\u2010hydroxytryptamine receptor 4 (5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>4) agonist, which is shown to improve upper abdominal symptoms. However, effect of mosapride on gastric accommodation was not clear. We tested the hypothesis that mosapride enhances the gastric accommodation in normal individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen male healthy volunteers completed this study. Single administration of mosapride or placebo was performed randomly with more than 1\u2010week interval. Subjects swallowed a triple\u2010lumen polyvinyl tube with a polyethylene bag. The bag was positioned in the proximal stomach and the minimal distending pressure (<jats:styled-content style=\"fixed-case\">MDP<\/jats:styled-content>) was determined. The ramp distension starting from the <jats:styled-content style=\"fixed-case\">MDP<\/jats:styled-content> was then performed and subjects were instructed to score their perception using ordinate scales. Next the intra\u2010bag pressure was set at <jats:styled-content style=\"fixed-case\">MDP<\/jats:styled-content> + 2\u00a0mmHg and a liquid meal was administered 30\u00a0min later, and the intra\u2010bag volume was recorded for 60\u00a0min. We compared the <jats:styled-content style=\"fixed-case\">MDP<\/jats:styled-content>, perception scores, and the intra\u2010bag volume changes by administering placebo and mosapride.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Minimal distending pressure was not significantly different in subjects receiving mosapride or placebo. Treatment with mosapride had no effect on intra\u2010bag pressures or volumes inducing first sensation or discomfort. Gastric accommodation, expressed as the difference between pre\u2010 and postmeal intra\u2010bag volumes, and the percent change of the intra\u2010bag volumes by the meal was significantly enhanced by mosapride compared with placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>This is the first study clearly demonstrating that single administration of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>4 agonist can enhance gastric accommodation in humans. (Umin.ac.jp, number UMIN000014063)<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12623","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T06:14:59Z","timestamp":1440483299000},"page":"1303-1309","source":"Crossref","is-referenced-by-count":21,"title":["Effect of 5\u2010hydroxytryptamine receptor 4 agonist mosapride on human gastric accommodation"],"prefix":"10.1111","volume":"27","author":[{"given":"T.","family":"Amano","sequence":"first","affiliation":[{"name":"Department of Gastroenterology National Center of Neurology and Psychiatry Tokyo Japan"},{"name":"Department of Behavioral Medicine Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ariga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Center of Neurology and Psychiatry Tokyo Japan"},{"name":"Department of Behavioral Medicine Tohoku University Graduate School of 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