{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:12:12Z","timestamp":1776082332113,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T00:00:00Z","timestamp":1438041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Rome III criteria for functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>), published in 2006, immediately generated controversy but have arguably helped to jump start the field in terms of mechanistic and therapeutic research. One controversy has surrounded the veracity of <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> symptom subgroups and their overlap. In clinical practice the overlap of postprandial distress syndrome (<jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content>) and epigastric pain syndrome (<jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>) is striking. In this issue, results from Belgium suggest overlap can be reduced by reclassifying those who have postprandial pain or nausea as <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content>, and meal\u2010related symptoms predominate in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>. This is consistent with other objective experimental observations. The realization most <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> occurs postmeal ingestion is driving a new conceptualization of the syndrome. For example, the observation there is an excess of duodenal eosinophils in <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content> has been confirmed, with recent observations implicating increased duodenal permeability and immune activation. The link between <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content> and anxiety, not identified in <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>, provides yet further evidence for distinct pathophysiological entities. While symptom\u2010based criteria likely need refinement, the recognition of <jats:styled-content style=\"fixed-case\">PDS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content> has promoted exciting progress.<\/jats:p>","DOI":"10.1111\/nmo.12641","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:48:10Z","timestamp":1438130890000},"page":"1052-1056","source":"Crossref","is-referenced-by-count":11,"title":["Functional dyspepsia and the Rome criteria: a success story"],"prefix":"10.1111","volume":"27","author":[{"given":"N. 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