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However, its safe dietary concentration and its toxicity, including its possible implication in the recent metabolic syndrome pandemia, is still a controversial issue. Therefore, a deep knowledge of its effects upon regular dietary use is needed. Our aim was to evaluate the effects of chronic exposure to<jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content>on feeding behavior, abdominal fat, gastrointestinal motility, and cardiovascular function in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two groups of adult male Wistar rats were used: control and treated with<jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content>(4\u00a0g\/L in drinking water) for 6\u00a0weeks. Different functional parameters were determined and the histological structure was analyzed in tissues of interest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Compared to control animals, chronic<jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content>increased water intake but did not modify food ingestion or body weight gain. Neither the abdominal fat volume nor the fat fraction, measured by magnetic resonance imaging, was modified by<jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content>. Monosodium glutamate did not alter general gastrointestinal motility, but significantly increased the colonic response to mechanical stimulation. It slightly reduced endothelium\u2010dependent relaxation in aorta, without significantly modifying any other cardiovascular parameters. No significant histological alterations were detected in salivary glands, intestinal wall, aorta, heart, and kidney.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Chronic treatment with<jats:styled-content style=\"fixed-case\">MSG<\/jats:styled-content>in the adult rat increased water intake. This supports its potential to improve acceptance of low\u2010fat regimens and to increase hydration in the elderly and sportspeople, often at risk of dehydration. Changes in colonic contractility and cardiovascular function could have some long\u2010term repercussions warranting further research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12653","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T03:27:04Z","timestamp":1440473224000},"page":"1559-1570","source":"Crossref","is-referenced-by-count":18,"title":["Effects of chronic dietary exposure to monosodium glutamate on feeding behavior, adiposity, gastrointestinal motility, and cardiovascular function in healthy adult rats"],"prefix":"10.1111","volume":"27","author":[{"given":"V.","family":"L\u00f3pez\u2010Miranda","sequence":"first","affiliation":[{"name":"\u00c1rea de Farmacolog\u00eda y Nutrici\u00f3n y Unidad Asociada al Instituto de Qu\u00edmica M\u00e9dica(IQM) y al Centro de Investigaci\u00f3n de Alimentos (CIAL) del Consejo Superior de Investigaciones Cient\u00edficas (CSIC) Universidad Rey Juan Carlos Alcorc\u00f3n Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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