{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:58:05Z","timestamp":1790517485777,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T00:00:00Z","timestamp":1442361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Gastrointestinal (\n GI<\/jats:styled-content>\n ) manifestations are found in Ehlers Danlos syndrome (\n EDS<\/jats:styled-content>\n ) hypermobility subtype (\n HM<\/jats:styled-content>\n ). We aimed to assess associations between\n EDS HM<\/jats:styled-content>\n and other\n EDS<\/jats:styled-content>\n subtypes with\n GI<\/jats:styled-content>\n manifestations.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We reviewed medical records of\n EDS<\/jats:styled-content>\n patients evaluated at Mayo Clinic's Medical Genetics Clinic 1994\u20132013. We extracted information regarding\n EDS<\/jats:styled-content>\n subtypes,\n GI<\/jats:styled-content>\n manifestations, and treatments.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n We identified 687 patients; 378 (56%) had associated\n GI<\/jats:styled-content>\n manifestations (female 86.8%, diagnosis mean age 29.6 years). Of the patients identified, 58.9% (43\/73) had\n EDS<\/jats:styled-content>\n classic, 57.5% (271\/471)\n EDS HM<\/jats:styled-content>\n , 47.3% (27\/57)\n EDS<\/jats:styled-content>\n vascular subtypes. In addition, 86 patients had\n EDS<\/jats:styled-content>\n that could not be classified in any of those three subtypes. Commonest\n GI<\/jats:styled-content>\n symptoms were: abdominal pain (56.1%), nausea (42.3%), constipation (38.6%), heartburn (37.6%), and irritable bowel syndrome\u2010like symptoms (27.5%). Many\n GI<\/jats:styled-content>\n symptoms were commoner in\n EDS HM<\/jats:styled-content>\n than the other subtypes together. Among 37.8% of the 378 patients who underwent esophagogastroduodenoscopy, the commonest abnormalities were gastritis, hiatal hernia and reflux esophagitis. Abnormal gastric emptying was observed in 22.3% (17\/76): 11.8% delayed and 10.5% accelerated. Colonic transit was abnormal in 28.3% (13\/46): 19.6% delayed and 8.7% accelerated. Rectal evacuation disorder was confirmed in 18\/30 patients who underwent anorectal manometry. Angiography showed aneurysms in abdominal vessels in\n EDS<\/jats:styled-content>\n vascular type. Proton pump inhibitors (38%) and drugs for constipation (23%) were the most commonly used medications. A minority underwent colectomy (2.9%) or small bowel surgery (4%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n \n EDS HM<\/jats:styled-content>\n and other subtypes should be considered in patients with chronic functional\n GI<\/jats:styled-content>\n symptoms and abdominal vascular lesions.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.12665","type":"journal-article","created":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T01:17:40Z","timestamp":1442452660000},"page":"1657-1666","source":"Crossref","is-referenced-by-count":143,"title":["Ehlers Danlos syndrome and gastrointestinal manifestations: a 20\u2010year experience at Mayo Clinic"],"prefix":"10.1111","volume":"27","author":[{"given":"A. D.","family":"Nelson","sequence":"first","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Mouchli","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Valentin","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Deyle","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Pichurin","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Acosta","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(09)60187-X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2007.12.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33070"},{"key":"e_1_2_10_6_1","first-page":"1777","article-title":"The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS)","volume":"27","author":"Grahame R","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00235-3"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg370"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01562.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33231"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01421.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh279"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12535"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.021"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.01.014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080321"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90717-Y"}],"container-title":["Neurogastroenterology & Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12665","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T03:53:24Z","timestamp":1695527604000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,16]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/nmo.12665"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12665","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725794822.793521228","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.725794822.793510256","asserted-by":"object"}]},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,16]]}}}