{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:01:06Z","timestamp":1791475266764,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,20]],"date-time":"2015-09-20T00:00:00Z","timestamp":1442707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["R01 DK068055"],"award-info":[{"award-number":["R01 DK068055"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000135"],"award-info":[{"award-number":["UL1 TR000135"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Acetylcholinesterase inhibitors (\n                      <jats:styled-content style=\"fixed-case\">ACI<\/jats:styled-content>\n                      s), e.g., neostigmine, are known to increase upper and lower gastrointestinal (\n                      <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\n                      ) motility and are used to treat acute colonic pseudoobstruction. However, their effects on gastroduodenal motility in humans are poorly understood. Our hypotheses were that, in patients with suspected\n                      <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\n                      motility disorders, neostigmine increases gastric and small intestinal motor activity, and these effects are greater in patients with cardiovagal neuropathy, reflecting denervation sensitivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this open label study, the effects of neostigmine (1 mg intravenously) on gastroduodenal motor activity recorded with manometry were assessed in 28 patients with a suspected\n                      <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\n                      motility disorder. Cardiovagal function was assessed with the heart rate response to deep breathing and\n                      <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\n                      transit by scintigraphy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      The final diagnoses were gastroparesis (6 patients), gastroparesis with intestinal neuropathy (3 patients), intestinal neuropathy or pseudoobstruction (5 patients), functional dyspepsia (6 patients), chronic abdominal pain (3 patients), mechanical small intestinal obstruction (3 patients), and pelvic floor dysfunction (2 patients). Neostigmine increased both antral and intestinal phasic pressure activity (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Neostigmine increased antral and intestinal pressure activity in 81% and 50% of patients with reduced postprandial antral and intestinal contractile responses to meal, respectively. The antroduodenal pressure response to neostigmine was not higher in patients with cardiovagal dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>\n                      Neostigmine increased antral and intestinal motor activity in patients with hypomotility, including intestinal dysmotility. These responses to neostigmine were not greater in patients with cardiovagal dysfunction. The use of longer\u2010acting\n                      <jats:styled-content style=\"fixed-case\">ACI<\/jats:styled-content>\n                      s for treating antroduodenal dysmotility warrant further study.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12669","type":"journal-article","created":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T07:00:23Z","timestamp":1442818823000},"page":"1736-1746","source":"Crossref","is-referenced-by-count":56,"title":["Effect of neostigmine on gastroduodenal motility in patients with suspected gastrointestinal motility disorders"],"prefix":"10.1111","volume":"27","author":[{"given":"G.","family":"Parthasarathy","sequence":"first","affiliation":[{"name":"Clinical and Enteric Neuroscience Translational and Epidemiological Research Program (C.E.N.T.E.R.) 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