{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:05:39Z","timestamp":1776485139668,"version":"3.51.2"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Segmental distribution of colorectal volume is relevant in a number of diseases, but clinical and experimental use demands robust reliability and validity. Using a novel semi\u2010automatic magnetic resonance imaging\u2010based technique, the aims of this study were to describe: (i) inter\u2010individual and intra\u2010individual variability of segmental colorectal volumes between two observations in healthy subjects and (ii) the change in segmental colorectal volume distribution before and after defecation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The inter\u2010individual and intra\u2010individual variability of four colorectal volumes (cecum\/ascending colon, transverse, descending, and rectosigmoid colon) between two observations (separated by 52\u00a0\u00b1\u00a010) days was assessed in 25 healthy males and the effect of defecation on segmental colorectal volumes was studied in another seven healthy males.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>No significant differences between the two observations were detected for any segments (All <jats:italic>p<\/jats:italic>\u00a0<jats:italic>&gt;<\/jats:italic>\u00a00.05). Inter\u2010individual variability varied across segments from low correlation in cecum\/ascending colon (intra\u2010class correlation coefficient [<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>]\u00a0=\u00a00.44) to moderate correlation in the descending colon (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\u00a0=\u00a00.61) and high correlation in the transverse (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\u00a0=\u00a00.78), rectosigmoid (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\u00a0=\u00a00.82), and total volume (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\u00a0=\u00a00.85). Overall intra\u2010individual variability was low (coefficient of variance\u00a0=\u00a09%). After defecation the volume of the rectosigmoid decreased by 44% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003). The change in rectosigmoid volume was associated with the true fecal volume (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Imaging of segmental colorectal volume, morphology, and fecal accumulation is advantageous to conventional methods in its low variability, high spatial resolution, and its absence of contrast\u2010enhancing agents and irradiation. Hence, the method is suitable for future clinical and interventional studies and for characterization of defecation physiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12673","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T14:51:19Z","timestamp":1441896679000},"page":"1755-1763","source":"Crossref","is-referenced-by-count":34,"title":["Quantification and variability in colonic volume with a\u00a0novel magnetic resonance imaging method"],"prefix":"10.1111","volume":"27","author":[{"given":"M.","family":"Nilsson","sequence":"first","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. H.","family":"Sandberg","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gram","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Fr\u00f8kj\u00e6r","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Radiology Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. R.","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Krogh","sequence":"additional","affiliation":[{"name":"Neurogastroenterology Unit Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Brock","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Drug Design and Pharmacology University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Drewes","sequence":"additional","affiliation":[{"name":"Mech\u2010Sense Department of Gastroenterology and Hepatology Aalborg University Hospital Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.05.054"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.10.10.842"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3928\/0090-4481-19871001-07"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00177370"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00341271"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00290185"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2012.01962.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00341204"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1318.2003.00443.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2003.00381.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12243"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12249"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00048.2014"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.08.005"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.386"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261\u2010015\u20100475\u2010z"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696990903430481"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-6-12"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750025327"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.03.008"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.46.6.454"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1191\/026921598672178340"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_10_25_1","volume-title":"Statistical Methods for Health Care Research","author":"Munro B","year":"2005"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2009.00189.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0020-2"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.558110"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.10.028"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2014.00049"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.1998.00105.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00147.2010"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(79)90162-8"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02049820"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-011-0006-4"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2008.00495.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2013.851082"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12673","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T14:08:40Z","timestamp":1696255720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,10]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/nmo.12673"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12673","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,10]]}}}