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Early\u2010life stress can be recapitulated in animals using the maternal separation (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) model, exhibiting many key phenotypic outcomes including visceral hypersensitivity and anxiety\u2010like behaviors. The molecular mechanisms of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> are unclear, but recent studies point to a role for epigenetics. Histone acetylation is a key epigenetic mark that is altered in numerous stress\u2010related disease states. Here, we investigated the role of histone acetylation in early\u2010life stress\u2010induced visceral hypersensitivity. Interestingly, increased number of pain behaviors and reduced threshold of visceral sensation were associated with alterations in histone acetylation in the lumbosacral spinal cord, a key region in visceral pain processing. Moreover, we also investigated whether the histone deacetylase (<jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>) inhibitor, suberoylanilide hydroxamic acid (<jats:styled-content style=\"fixed-case\">SAHA<\/jats:styled-content>), could reverse early\u2010life stress\u2010induced visceral hypersensitivity and stress\u2010induced fecal pellet output in the <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> model. Significantly, <jats:styled-content style=\"fixed-case\">SAHA<\/jats:styled-content> reversed both of these parameters. Taken together, these data describe, for the first time, a key role of histone acetylation in the pathophysiology of early\u2010life stress\u2010induced visceral hypersensitivity in a well\u2010established model of <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>. These findings will inform new research aimed at the development of novel pharmaceutical approaches targeting the epigenetic machinery for novel anti\u2010<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> drugs.<\/jats:p>","DOI":"10.1111\/nmo.12675","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T05:23:15Z","timestamp":1443158595000},"page":"1831-1836","source":"Crossref","is-referenced-by-count":88,"title":["Early\u2010life stress\u2010induced visceral hypersensitivity and anxiety behavior is reversed by histone deacetylase inhibition"],"prefix":"10.1111","volume":"27","author":[{"given":"R. D.","family":"Moloney","sequence":"first","affiliation":[{"name":"Laboratory of Neurogastroenterology APC Microbiome Institute University College Cork Cork Ireland"},{"name":"Department of Psychiatry and Neurobehavioural Science University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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