{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:06:02Z","timestamp":1791309962219,"version":"4.3.1"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T00:00:00Z","timestamp":1443139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004602","name":"Program for New Century Excellent Talents in University","doi-asserted-by":"publisher","award":["NCET\u201012\u20100260"],"award-info":[{"award-number":["NCET\u201012\u20100260"]}],"id":[{"id":"10.13039\/501100004602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Task\u2010related brain imaging research has implicated abnormal central processing of visceral sensation in irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>). However, how brain function of <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients is altered during resting\u2010state remains to be determined. We investigated spontaneous brain activity of patients with <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> using regional homogeneity (ReHo) analysis in resting\u2010state functional magnetic resonance imaging (rs\u2010<jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010one patients with diarrhea\u2010predominant <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> and 32 age\u2010 and sex\u2010 matched healthy controls underwent clinical assessments and rs\u2010<jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content> scanning. ReHo maps were acquired by calculating the Kendall's coefficient of concordance and compared between the <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> group and the control group. The effects of psychological disturbance on group differences were assessed by including anxiety and depression levels as covariates in the statistical analyses. Multiple regression analyses were conducted to examine the relationship between ReHo values and disease duration, symptom severity, and pain intensity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Compared with controls, <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients showed increased ReHo in the postcentral gyrus and thalamus and decreased ReHo in the anterior cingulate cortex and prefrontal cortex. The inclusion of anxiety and depression as covariates did not alter ReHo differences between the two groups. Furthermore, significant correlations were found between clinical indices and ReHo values in some brain regions in the <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients have abnormal local synchronization of spontaneous brain activity in regions involved in visceral afferent processing, emotional arousal, and cognitive modulation. Combining rs\u2010<jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content> and ReHo analysis seems to be a valuable approach to investigate the neural basis of <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12692","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T05:23:16Z","timestamp":1443158596000},"page":"1796-1803","source":"Crossref","is-referenced-by-count":44,"title":["Abnormal regional homogeneity in patients with irritable bowel syndrome: A resting\u2010state functional <scp>MRI<\/scp> study"],"prefix":"10.1111","volume":"27","author":[{"given":"J.","family":"Ke","sequence":"first","affiliation":[{"name":"Department of Medical Imaging Jinling Hospital Medical School of Nanjing University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Medical 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Nanjing University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Jinling Hospital Medical School of Nanjing University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.029"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_10_4_1","first-page":"71","article-title":"The epidemiology of irritable bowel syndrome","volume":"6","author":"Canavan C","year":"2014","journal-title":"Clin 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