{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:02:17Z","timestamp":1781568137558,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T00:00:00Z","timestamp":1445385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA149956"],"award-info":[{"award-number":["CA149956"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe burn injury has been demonstrated to delay gastric emptying. The aim of this study was to investigate effects and cellular mechanisms of auricular electroacupuncture (<jats:styled-content style=\"fixed-case\">AEA<\/jats:styled-content>) at the acupoints innervated by the auricular branch of vagus nerve on burn\u2010induced gastric dysmotility in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Propranolol (<jats:italic>\u03b2<\/jats:italic>\u2010adrenoceptor antagonist) was injected intraperitoneally after the rats underwent burn injury. All experiments were performed 6 h following burn\/sham burn injury. <jats:styled-content style=\"fixed-case\">AEA<\/jats:styled-content> was performed at bilateral auricular acupoints for 45 min. Electrocardiogram was recorded for 30 min. Plasma hormones were measured; cyclooxygenase (<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>)\u20102 expressions in gastric tissue were measured using western blotting and real\u2010time <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>(i) Burn injury delayed gastric emptying (<jats:italic>p<\/jats:italic> = 0.006) and <jats:styled-content style=\"fixed-case\">AEA<\/jats:styled-content> increased gastric emptying by 49% (<jats:italic>p<\/jats:italic> = 0.045). (ii) Burn injury evoked a significant elevation in plasma noradrenaline, which was suppressed by <jats:styled-content style=\"fixed-case\">AEA<\/jats:styled-content>. (iii) Burn injury significantly increased protein and <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expressions of <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 in gastric fundus and antrum. <jats:styled-content style=\"fixed-case\">AEA<\/jats:styled-content> suppressed burn\u2010induced increase in protein expressions, but not <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expressions of <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Burn injury delays gastric emptying by up\u2010regulating <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 attributed to sympathetic overactivity. <jats:styled-content style=\"fixed-case\">AEA<\/jats:styled-content> improves burn\u2010induced delay in gastric emptying, possibly mediated via the sympathetic\u2010<jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12693","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T02:59:47Z","timestamp":1445482787000},"page":"36-42","source":"Crossref","is-referenced-by-count":25,"title":["Auricular vagal nerve stimulation ameliorates burn\u2010induced gastric dysmotility via sympathetic\u2010<scp>COX<\/scp>\u20102 pathways in rats"],"prefix":"10.1111","volume":"28","author":[{"given":"H.","family":"Li","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine University of Texas Medical Branch Galveston TX USA"},{"name":"Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Yin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine University of Texas Medical Branch Galveston TX USA"},{"name":"Division of Gastroenterology and Hepatology Johns Hopkins School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine University of Texas Medical Branch Galveston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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