{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:58:34Z","timestamp":1790517514094,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T00:00:00Z","timestamp":1445990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mayo Clinic in Arizona Intramural Clinical Research Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There have been conflicting results from studies that have evaluated psychological disturbances in functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>). We conducted a comprehensive survey of psychological measures in patients undergoing gastric emptying testing (<jats:styled-content style=\"fixed-case\">GET<\/jats:styled-content>) in order to determine the relationship among psychological distress, gastric emptying, and dyspeptic symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients referred for <jats:styled-content style=\"fixed-case\">GET<\/jats:styled-content> were prospectively enrolled. Details regarding patient characteristics, health care utilization, dyspeptic symptoms, quality of life, and psychological dysfunction were obtained. Depression, anxiety, somatization, stress, positive and negative affect, and alexithymia were queried using validated questionnaires. We compared those dyspeptic patients who met Rome III criteria for <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> to those who did not meet these criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Two hundred and nine patients (160 female; mean age 46.6 years \u00b1 17.3 years) participated. Around 151 patients (72%) met Rome III criteria for <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>. In the entire group, a high level of depression, anxiety, somatization, and perceived stress was present compared to population norms. Health care seeking behavior and symptom severity were greater in those with <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> and quality of life was lower compared to non\u2010<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>. Gastric emptying did not differentiate the two groups and similar degrees of psychological distress were present whether emptying was delayed or normal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>In patients referred for <jats:styled-content style=\"fixed-case\">GET<\/jats:styled-content>, substantial psychological distress is present. The degree of distress was similar regardless of whether the patient met Rome III <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> criteria or not. Further evaluation of psychological dysfunction in <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content> patients may lead to improved diagnosis and determination of the most appropriate treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12709","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T02:16:15Z","timestamp":1446084975000},"page":"196-205","source":"Crossref","is-referenced-by-count":24,"title":["Psychological distress in Rome III functional dyspepsia patients presenting for testing of gastric emptying"],"prefix":"10.1111","volume":"28","author":[{"given":"J. K.","family":"Dibaise","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Mayo Clinic in Arizona Scottsdale AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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