{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:08:05Z","timestamp":1780412885108,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment of gastro\u2010esophageal reflux refractory symptoms is challenging. This monocenter retrospective study assessed the value of preoperative pH\u2010impedance monitoring \u2018on\u2019 therapy to predict functional outcome after laparoscopic fundoplication in patients with refractory reflux symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a preoperative pH\u2010impedance monitoring \u2018on\u2019 proton pump inhibitors (<jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>s) twice daily were assessed at least 6 months after a laparoscopic fundoplication for refractory reflux symptoms. Failure of fundoplication was defined by a Visick score &gt; 2. Postoperative symptoms were assessed by the reflux disease questionnaire (<jats:styled-content style=\"fixed-case\">RDQ<\/jats:styled-content>). The pH\u2010impedance parameters analyzed were the number of reflux events (total, acid, non\u2010acid), esophageal acid exposure time, esophageal bolus exposure time, and symptom\u2010reflux association defined by symptom index (<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>) &gt;50% and symptom association probability (<jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content>) &gt;95%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Thirty\u2010three patients (18 female patients, median age 46 years) were assessed after a mean follow\u2010up of 41.3 (range 7\u2013102.2) months. Seven (21.2%) patients were considered as failures. Compared to patients with favorable outcome, these patients were more often \u2018on\u2019 <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content> therapy (86% <jats:italic>vs<\/jats:italic> 23%, <jats:italic>p<\/jats:italic> &lt; 0.05) and had higher <jats:styled-content style=\"fixed-case\">RDQ<\/jats:styled-content> scores in each domain: heartburn (<jats:italic>p<\/jats:italic> &lt; 0.05), regurgitation (<jats:italic>p<\/jats:italic> &lt; 0.05) and dyspepsia (<jats:italic>p<\/jats:italic> &lt; 0.05). A positive <jats:styled-content style=\"fixed-case\">SAP<\/jats:styled-content> was the only pH\u2010impedance parameter statistically associated with successful postoperative outcome (<jats:italic>p<\/jats:italic> = 0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>On therapy, a preoperative positive symptom association probability is the only pH\u2010impedance parameter associated with favorable outcome after laparoscopic fundoplication for refractory reflux symptoms. These results should be confirmed by prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12715","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T09:34:41Z","timestamp":1446543281000},"page":"146-152","source":"Crossref","is-referenced-by-count":45,"title":["24\u2010hour pH\u2010impedance monitoring on therapy to select patients with refractory reflux symptoms for antireflux surgery. A single center retrospective study"],"prefix":"10.1111","volume":"28","author":[{"given":"M.","family":"Desjardin","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Department H\u00f4pital Saint Andr\u00e9 Centre Hospitalier Universitaire de Bordeaux and Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Luc","sequence":"additional","affiliation":[{"name":"Digestive Surgery Department H\u00f4pital Haut L\u00e9v\u00eaque Centre Hospitalier Universitaire de Bordeaux and Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Collet","sequence":"additional","affiliation":[{"name":"Digestive Surgery Department H\u00f4pital Haut L\u00e9v\u00eaque Centre Hospitalier Universitaire de Bordeaux and Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Zerbib","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department H\u00f4pital Saint Andr\u00e9 Centre Hospitalier Universitaire de Bordeaux and Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9178669"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07665.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199802000-00004"},{"key":"e_1_2_9_5_1","volume-title":"The 2000 Gallup Study of Consumers' Use of Stomach Relief Products","author":"Organization TG","year":"2000"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.145581"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301897"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.121"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.235630"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.09.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7296"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(01)80083-4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6684"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-2861-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5493"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02677.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.033290"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.10.041"},{"key":"e_1_2_9_19_1","first-page":"358","article-title":"The symptom index: a clinically important parameter of ambulatory 24\u2010hour esophageal pH monitoring","volume":"83","author":"Wiener GJ","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90815-X"},{"key":"e_1_2_9_21_1","first-page":"266","article-title":"A study of the failures after gastrectomy","volume":"3","author":"Visick AH","year":"1948","journal-title":"Ann R Coll Surg Engl"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-14-17"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(99)80071-7"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2004.01.010"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-008-0583-y"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.08.029"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.087668"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00711.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12080"}],"container-title":["Neurogastroenterology &amp; 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