{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:24:02Z","timestamp":1781832242936,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>) is the most common functional gastrointestinal disorder worldwide. The global prevalence of<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>is estimated to be as high as 15%. For many patients,<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>is a chronic disorder which can significantly reduce quality of life. Just as important as the effects on any one individual,<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>also places a significant impact on the population as a whole with its negative effects on the health care system. Irritable bowel syndrome is categorized into one of three main categories:<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>with diarrhea,<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>with constipation, and<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>with mixed bowel habits. Patients with diarrhea\u2010predominant<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010D) comprise a substantial proportion of the overall<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>population. A number of therapeutic options exist to treat the symptoms of abdominal pain, bloating, diarrhea, and fecal urgency, including non\u2010pharmacologic therapies such as dietary changes and probiotics, or pharmacologic therapies such as loperamide and alosetron. However, many patients have persistent symptoms despite these therapies. This unmet need led to the development of eluxadoline, a mu\u2010opioid receptor agonist\/delta\u2010opioid receptor antagonist\/kappa\u2010receptor agonist. Approved by the<jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content>in May 2015, this medication shows promise in the treatment of diarrhea\u2010predominant<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>for both men and women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This monograph will briefly review the impact of<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>, discuss current treatments for<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010D, and then focus on the pharmacology, clinical efficacy and safety of eluxadoline. Potential mechanisms related to rare events of acute pancreatitis or elevated liver tests will be discussed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12716","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T11:11:51Z","timestamp":1450782711000},"page":"26-35","source":"Crossref","is-referenced-by-count":40,"title":["Emerging treatments in neurogastroenterology: eluxadoline \u2013 a new therapeutic option for diarrhea\u2010predominant<scp>IBS<\/scp>"],"prefix":"10.1111","volume":"28","author":[{"given":"B. 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