{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:49:35Z","timestamp":1785527375248,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T00:00:00Z","timestamp":1448496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recently, cine magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) has shown promise for visualizing movement of the colonic wall, although assessment of data has been subjective and observer dependent. This study aimed to develop an objective and semi\u2010automatic imaging metric of ascending colonic wall movement, using image registration techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cine balanced turbo field echo <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> images of ascending colonic motility were acquired over 2\u00a0min from 23 healthy volunteers (<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>s) at baseline and following two different macrogol stimulus drinks (11 <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>s drank 1\u00a0L and 12 <jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>s drank 2\u00a0L). Motility metrics derived from large scale geometric and small scale pixel movement parameters following image registration were developed using the post ingestion data and compared to observer grading of wall motion. Inter and intra\u2010observer variability in the highest correlating metric was assessed using Bland\u2013Altman analysis calculated from two separate observations on a subset of data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>All the metrics tested showed significant correlation with the observer rating scores. Line analysis (<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>) produced the highest correlation coefficient of 0.74 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.55\u20130.86), <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 (Spearman Rho). Bland\u2013Altman analysis of the inter\u2010 and intra\u2010observer variability for the <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> metric, showed almost zero bias and small limits of agreement between observations (\u22120.039 to 0.052 intra\u2010observer and \u22120.051 to 0.054 inter\u2010observer, range of measurement 0\u20130.353).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> index of colonic motility derived from cine <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> registered data provides a quick, accurate and non\u2010invasive method to detect wall motion within the ascending colon following a colonic stimulus in the form of a macrogol drink.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12727","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T03:37:55Z","timestamp":1448595475000},"page":"327-335","source":"Crossref","is-referenced-by-count":25,"title":["Colon wall motility: comparison of novel quantitative semi\u2010automatic measurements using cine <scp>MRI<\/scp>"],"prefix":"10.1111","volume":"28","author":[{"given":"C. L.","family":"Hoad","sequence":"first","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre School of Physics and Astronomy University of Nottingham Nottingham UK"},{"name":"NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases Nottingham University Hospitals Trust and the University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Menys","sequence":"additional","affiliation":[{"name":"Centre for Medical Imaging Division of Medicine University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Garsed","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases Nottingham University Hospitals Trust and the University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Marciani","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases Nottingham University Hospitals Trust and the University of Nottingham Nottingham UK"},{"name":"Nottingham Digestive Diseases Centre School of Medicine University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Hamy","sequence":"additional","affiliation":[{"name":"Centre for Medical Imaging Division of Medicine University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Murray","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre School of Physics and Astronomy University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Costigan","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre School of Physics and Astronomy University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Centre for Medical Imaging Division of Medicine University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Major","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases Nottingham University Hospitals Trust and the University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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