{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T14:46:36Z","timestamp":1696257996709},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T00:00:00Z","timestamp":1448496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["11\/RFP\/3115"],"award-info":[{"award-number":["11\/RFP\/3115"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sacral nerve stimulation has become a first line treatment for fecal incontinence, however, its effect on the motor function of the anorectum is uncertain. The aim of this study was to apply acute lumbosacral nerve stimulation in an animal model and to determine its effect on the external and internal anal sphincter forces, the rectoanal inhibitory and excitatory reflexes, and the slow wave frequency of the internal anal sphincter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lumbosacral nerve stimulation was applied to 16 nulliparous female rats. A novel <jats:italic>in\u00a0vivo<\/jats:italic> preparation was designed to allow simultaneous monitoring of external and internal anal sphincter forces. The effect of rectal distension on the two anal sphincters was also studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Lumbosacral nerve stimulation delivered at either S<jats:sub>1<\/jats:sub> or L<jats:sub>6<\/jats:sub> in rodents did not affect sphincter forces, rectoanal reflexes or slow wave frequency of anal canal smooth muscle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>The absence of effect on the motor pathways of continence suggests that the mechanism of action is predominantly on sensory feedback mechanisms from the anorectum, thereby increasing cortical awareness of the pelvic floor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12733","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T03:38:56Z","timestamp":1448595536000},"page":"358-363","source":"Crossref","is-referenced-by-count":5,"title":["Acute lumbosacral nerve stimulation does not affect anorectal motor function in a rodent model"],"prefix":"10.1111","volume":"28","author":[{"given":"L. A.","family":"Devane","sequence":"first","affiliation":[{"name":"School of Medicine and Medical Science University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Evers","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Science University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. S.","family":"Scott","sequence":"additional","affiliation":[{"name":"National Centre for Bowel Research and Surgical Innovation and GI Physiology Unit Queen Mary College University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Knowles","sequence":"additional","affiliation":[{"name":"National Centre for Bowel Research and Surgical Innovation and GI Physiology Unit Queen Mary College University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"O'Connell","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Science University College Dublin Dublin Ireland"},{"name":"Centre for Colorectal Disease St Vincent's University Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F. X.","family":"Jones","sequence":"additional","affiliation":[{"name":"School of Medicine and Medical Science University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02048271"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2010.02518.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02239440"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02049725"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.16.6.482"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.272542"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2009.121"},{"key":"e_1_2_9_9_1","volume-title":"Studies of the Muscles of Continence and their Innervation in the Female Rat","author":"Buffini M","year":"2011"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181c3873c"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7536"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4757"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2011.02623.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318269d493"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200202000-00002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01952426"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9587"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01241.x"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12733","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:19:10Z","timestamp":1695568750000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,26]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/nmo.12733"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12733","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,26]]}}}