{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:28:03Z","timestamp":1790969283147,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T00:00:00Z","timestamp":1450137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Rouen University Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Anal manometry is the standard technique for evaluating anal sphincter function. However, the functional lumen imaging probe (Endo\n                      <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content>\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) can be used to measure sphincter distensibility during volume\u2010controlled distensions. Our aims were (i) to assess anal distensibility in patients with fecal incontinence (\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      ) and in healthy subjects using the Endo\n                      <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content>\n                      <jats:sup>\u00ae<\/jats:sup>\n                      and (ii) to compare the results with anal pressures measured by 3D high\u2010resolution manometry (3D\u2010\n                      <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content>\n                      ) to determine whether the Endo\n                      <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content>\n                      <jats:sup>\u00ae<\/jats:sup>\n                      was more sensitive and specific for diagnosing\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      than 3D\u2010\n                      <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Endo\n                      <jats:styled-content style=\"fixed-case\">FLIP<\/jats:styled-content>\n                      <jats:sup>\u00ae<\/jats:sup>\n                      and 3D\u2010\n                      <jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content>\n                      assessments of 34 female\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      patients and 40 healthy female subjects were performed. Anal distensibility was measured as the median cross\u2010sectional area at the narrowest point divided by the corresponding intra\u2010bag pressure at rest and during peak voluntary contraction and was expressed in mm\n                      <jats:sup>2<\/jats:sup>\n                      \/mmHg.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      A 40\u2010mL anal distensibility index was selected for further comparisons as it provided the best discrimination between the\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      patients and the healthy subjects. The index was significantly higher in the\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      patients than in the healthy subjects at rest (\n                      <jats:italic>p<\/jats:italic>\n                      = 1.10\n                      <jats:sup>\u22124<\/jats:sup>\n                      ) and during voluntary contraction (\n                      <jats:italic>p<\/jats:italic>\n                      = 1.10\n                      <jats:sup>\u22124<\/jats:sup>\n                      ). The index at rest and during voluntary contraction appeared to be more appropriate than anal pressures for discriminating between\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      patients and healthy subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions &amp; Inferences<\/jats:title>\n                    <jats:p>\n                      The present study confirmed that\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      is associated with an abnormally high distensibility index at rest and during voluntary contraction. The ability of the distensibility index to discriminate between\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      patients and healthy subjects was significantly better than anal pressure.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12740","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:26Z","timestamp":1450224026000},"page":"399-409","source":"Crossref","is-referenced-by-count":46,"title":["Do endoflip assessments of anal sphincter distensibility provide more information on patients with fecal incontinence than high\u2010resolution anal manometry?"],"prefix":"10.1111","volume":"28","author":[{"given":"G.","family":"Gourcerol","sequence":"first","affiliation":[{"name":"INSERM U1073 Service de Physiologie Digestive CHU Rouen INSERM CIC 0204 Rouen Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Granier","sequence":"additional","affiliation":[{"name":"INSERM U1073 Service de Physiologie Digestive CHU Rouen INSERM CIC 0204 Rouen Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Bridoux","sequence":"additional","affiliation":[{"name":"INSERM U1073 Service de Chirurgie Digestive CHU Rouen Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Menard","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Biostatistiques Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ducrott\u00e9","sequence":"additional","affiliation":[{"name":"INSERM U1073 Service d'H\u00e9pato\u2010Gastroent\u00e9rologie CHU Rouen Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Leroi","sequence":"additional","affiliation":[{"name":"INSERM U1073 Service de Physiologie Digestive CHU Rouen INSERM CIC 0204 Rouen Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199809000-00003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.190"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00950.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05450.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.01.069"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(66)80003-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00311.2006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-012-0871-0"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12028"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12063"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12258"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.04.054"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-1-200301070-00012-w1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050307"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310005631"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0746-4"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-009-0693-3"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.048"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1156"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000186281.09475.db"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2011.02623.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12270"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880180608"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.9.1031"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318237f37d"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnmo.12740","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nmo.12740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:19:33Z","timestamp":1695554373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nmo.12740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,15]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/nmo.12740"],"URL":"https:\/\/doi.org\/10.1111\/nmo.12740","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,15]]}}}