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In genetically predisposed individuals, an autoimmune response to an unknown inciting agent, perhaps a viral infection, results in inflammation and sometimes loss of myenteric plexus ganglia and neurons. The net result is varying degrees of inhibitory dysfunction, at times associated with imbalanced and exaggerated excitatory function, with manometrically distinct achalasia phenotypes on high resolution manometry. There is new evidence in the current issue of this Journal suggesting that type 1 achalasia, with esophageal outflow obstruction and absent esophageal body contractility, is an end\u2010stage phenotype from progression of type 2 achalasia, which is characterized by panesophageal compartmentalization of pressure in the untreated patient, and partial recovery of peristalsis after treatment. Esophageal outflow obstruction with premature peristalsis (type 3 achalasia) or intact peristalsis may result from plexitis in the myenteric plexus but can also be encountered in other settings including chronic opioid medication usage and structural processes at the esophagogastric junction and distally. In most instances when idiopathic esophageal outflow obstruction is confirmed, some form of pharmacologic manipulation or disruption of the <jats:styled-content style=\"fixed-case\">LES<\/jats:styled-content> provides durable symptom relief. This review will focus on current understanding of pathophysiology, diagnosis, and principles of management of achalasia in light of emerging literature on the topic.<\/jats:p>","DOI":"10.1111\/nmo.12750","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T11:11:51Z","timestamp":1450782711000},"page":"4-11","source":"Crossref","is-referenced-by-count":48,"title":["Achalasia: new perspectives on an old disease"],"prefix":"10.1111","volume":"28","author":[{"given":"C. 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