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In 2013, the use of acotiamide was approved by the Japanese health insurance system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      The aim of this review is to summarize the present staus of basic and clinical approach to acotiamide for the treatment of functional dyspepsia. The agent inhibits acetylcholinesterase\n                      <jats:italic>in vitro<\/jats:italic>\n                      and enhances muscle motility\n                      <jats:italic>ex vivo<\/jats:italic>\n                      . In phase\u2010II studies, 100 mg three times daily (t.i.d.) was determined to be the optimal dose for the treatment of\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      . In phase\u2010III studies, overall treatment efficacy (OTE) was significantly better in the acotiamide group (52.2%) than in the placebo group (34.8%). However, the mechanism of its efficacy needs to be further elucidated. Acotiamide effectively improved\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      symptoms, particularly postprandial distress syndrome symptoms, without causing major adverse effects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12756","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T19:40:44Z","timestamp":1452022844000},"page":"631-638","source":"Crossref","is-referenced-by-count":11,"title":["Emerging treatments in neurogastroenterology: Acotiamade, a novel treatment option for functional dyspepsia"],"prefix":"10.1111","volume":"28","author":[{"given":"M.","family":"Matsushita","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo 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