{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:27:54Z","timestamp":1785446874025,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:00:00Z","timestamp":1455235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004321","name":"Shire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The management of bloating is unclear and its relationship with patients' well\u2010being and treatment satisfaction independent of other abdominal symptoms is uncharacterized. We evaluated the association of bloating with patient\u2010reported outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010nine centers for functional gastrointestinal disorders joined the laxative inadequate relief survey. We enrolled 2203 consecutive outpatients with functional constipation (<jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>) or constipation\u2010predominant irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010C) in two cross\u2010sectional waves. Both wave 1 and 2 included the <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201012, the patient assessment of constipation\u2010symptoms (<jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SYM<\/jats:styled-content>), and the treatment satisfaction questionnaire for medication (<jats:styled-content style=\"fixed-case\">TSQM<\/jats:styled-content>\u20102). Wave 2 only included a global rating of change (<jats:styled-content style=\"fixed-case\">GRC<\/jats:styled-content>) scale to assess patients' assessment of efficacy concerning treatment switches occurred in the 3 months prior to the interview. Bloating in the abdomen was defined on the basis of <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SYM<\/jats:styled-content> item 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The average age was 50.1 years (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>, 16.7) and 82.1% of patients were women. The prevalence of bloating was 91.6% (<jats:italic>n<\/jats:italic> = 1970). Bloating was associated with <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201012 Physical Composite Score (<jats:italic>p<\/jats:italic> &lt; 0.01), <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201012 Mental Composite Score (<jats:italic>p<\/jats:italic> &lt; 0.01), <jats:styled-content style=\"fixed-case\">GRC<\/jats:styled-content> (<jats:italic>p<\/jats:italic> &lt; 0.01), Satisfaction with treatment effectiveness (<jats:italic>p<\/jats:italic> &lt; 0.01), convenience of administration (<jats:italic>p<\/jats:italic> &lt; 0.01), and side effects (<jats:italic>p<\/jats:italic> &lt; 0.01) after adjustment for possible confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Our data suggest that patients regard bloating as a key element in assessing clinical changes and treatments' efficacy as this symptom exerts a strong influence on patient\u2010reported outcomes independent of possible confounders and other symptoms of constipation. Our data provide the rationale to investigate the efficacy and tolerability of new treatments specifically addressing this important, yet disregarded, patients' complain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12758","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T08:53:13Z","timestamp":1455267193000},"page":"581-591","source":"Crossref","is-referenced-by-count":45,"title":["Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation\u2010predominant irritable bowel syndrome and functional constipation"],"prefix":"10.1111","volume":"28","author":[{"given":"L.","family":"Neri","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Community Health University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Iovino","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Salerno Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Laxative Inadequate Relief Survey (LIRS) Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.142810"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i39.14407"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2011.04637.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-8-671"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01009.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.07110.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310004209"},{"key":"e_1_2_10_9_1","first-page":"351","volume-title":"The Functional Gastrointestinal Disorders","author":"Thompson WG","year":"2000"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.75"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010011\u20109985\u20105"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.07.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614528175"},{"key":"e_1_2_10_14_1","volume-title":"Questionario sullo stato di salute SF\u201012","author":"Apolone G"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750025327"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2005.00066.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1179\/jmt.2009.17.3.163"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2007.01.008"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640613494200"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11938-004-0016-2"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01094.x"},{"key":"e_1_2_10_23_1","first-page":"G778","article-title":"5\u2010HT released by mucosal stimuli initiates peristalsis by activating 5\u2010HT4\/5\u2010HT1P receptors on sensory CGRP neurons","volume":"270","author":"Grider JR","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00708.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70251-4"},{"key":"e_1_2_10_26_1","first-page":"755","article-title":"Association of tegaserod with cardiovascular outcomes in a matched study of 18,221 treated and untreated patients","volume":"29","author":"Anderson JL","year":"2008","journal-title":"Eur Heart J"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12217"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01195.x"},{"key":"e_1_2_10_29_1","first-page":"49","article-title":"Role of prucalopride, a serotonin (5\u2010HT4) receptor agonist, for the treatment of chronic constipation","volume":"3","author":"Wong BS","year":"2010","journal-title":"Clin Exp Gastroenterol"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134349"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00269.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13167"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05985.x"}],"container-title":["Neurogastroenterology &amp; 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