{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:21:34Z","timestamp":1776777694686,"version":"3.51.2"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T00:00:00Z","timestamp":1452729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400582"],"award-info":[{"award-number":["81400582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470817"],"award-info":[{"award-number":["81470817"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Approximately one\u2010third of gastroesophageal reflux disease (\n GERD<\/jats:styled-content>\n ) patients have symptoms resistant to proton pump inhibitor (\n PPI<\/jats:styled-content>\n ). We used the high\u2010resolution manometry (\n HRM<\/jats:styled-content>\n ) and multichannel intraluminal impedance\u2010pH (\n MII<\/jats:styled-content>\n \u2010pH) monitoring to investigate potential predictors of\n PPI<\/jats:styled-content>\n failure in non\u2010erosive reflux disease (\n NERD<\/jats:styled-content>\n ) patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n One hundred and seventeen\n NERD<\/jats:styled-content>\n patients were included, within which there were 44\n PPI<\/jats:styled-content>\n failure patients. The symptomatic questionnaire GerdQ,\n HRM<\/jats:styled-content>\n and 24\u2010hour\n MII<\/jats:styled-content>\n \u2010pH monitoring were performed before\n PPI<\/jats:styled-content>\n therapy.\n PPI<\/jats:styled-content>\n failure was defined as persistent reflux symptoms for more than 1 day during the last week on esomeprazole (20 mg twice daily) for continuous 4 weeks. The predictors for\n PPI<\/jats:styled-content>\n failure were investigated by multivariable logistic regression analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n Proton pump inhibitor failure patients had lower body mass index (\n BMI<\/jats:styled-content>\n ) and more concomitant functional dyspepsia (\n FD<\/jats:styled-content>\n ) symptoms.\n PPI<\/jats:styled-content>\n failure patients had a higher percentage of type I esophagogastric junction (\n EGJ<\/jats:styled-content>\n ) morphology (\n p<\/jats:italic>\n = 0.005), increased\n EGJ<\/jats:styled-content>\n augmentation (\n p<\/jats:italic>\n = 0.000), higher prevalence of esophageal motility disorders (\n p<\/jats:italic>\n = 0.005) and a higher ratio of negative symptom index (\n SI<\/jats:styled-content>\n ,\n p<\/jats:italic>\n = 0.000). Multivariable regression analysis showed that concomitance of\n FD<\/jats:styled-content>\n symptoms,\n EGJ<\/jats:styled-content>\n augmentation and negative\n SI<\/jats:styled-content>\n were independent risk factors for\n PPI<\/jats:styled-content>\n failure in\n NERD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions & Inferences<\/jats:title>\n \n Approximately half of\n PPI<\/jats:styled-content>\n failure patients were found to have esophageal motility disorders in\n HRM<\/jats:styled-content>\n . The independent risk factors for\n PPI<\/jats:styled-content>\n failure in\n NERD<\/jats:styled-content>\n were concomitant\n FD<\/jats:styled-content>\n symptoms, increased\n EGJ<\/jats:styled-content>\n augmentation and negative\n SI<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nmo.12763","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T06:12:14Z","timestamp":1452838334000},"page":"674-679","source":"Crossref","is-referenced-by-count":16,"title":["Predictors of proton pump inhibitor failure in non\u2010erosive reflux disease: A study with impedance\u2010pH monitoring and high\u2010resolution manometry"],"prefix":"10.1111","volume":"28","author":[{"given":"Y.","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou Guangdong Province China"},{"name":"Department of Gastroenterology Shanxi Cancer Hospital Taiyuan Shanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The First Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9178669"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.145581"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32833ae2be"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02033.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.087668"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.43"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31815ea291"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01311.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01138.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.033290"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24841"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2012.02992.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.016"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.05.015"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0399-8320(05)80756-0"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.053355"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300798"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12267"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00749.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00711.x"}],"container-title":["Neurogastroenterology 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