{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:56:48Z","timestamp":1792051008547,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:00:00Z","timestamp":1455235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1064835"],"award-info":[{"award-number":["1064835"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with chronic intractable constipation experience severe and long\u2010lasting symptoms, which respond poorly to conventional therapeutic strategies. Detailed characterization of colonic motor patterns in such children has not yet been obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 18 children with chronic intractable constipation, a high\u2010resolution water\u2010perfused manometry catheter (36 sensors at 1.5\u2010cm intervals) was colonoscopically placed with the tip at the distal transverse colon. Colonic motor patterns were recorded for 2 h prior to and after a meal and then after colonic infusion of bisacodyl. These data were compared with previously published colonic manometry data from 12 healthy adult controls and 14 adults with slow\u2010transit constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>The postprandial number of the retrograde cyclic propagating motor pattern was significantly reduced in these children compared with healthy adults (children, 3.1 \u00b1 4.7\/h <jats:italic>vs<\/jats:italic> healthy adults, 34.7 \u00b1 45.8\/h; <jats:italic>p<\/jats:italic> &lt; 0.0001) but not constipated adults (4.5 \u00b1 5.6\/h; <jats:italic>p<\/jats:italic> = 0.9). The number of preprandial long\u2010single motor patterns was significantly higher (<jats:italic>p<\/jats:italic> = 0.003) in children (8.0 \u00b1 13.2\/h) than in healthy adults (0.4 \u00b1 0.9\/h) and in constipated adults (0.4 \u00b1 0.7\/h). Postprandial high\u2010amplitude propagating sequences (<jats:styled-content style=\"fixed-case\">HAPSs<\/jats:styled-content>) were rarely observed in children (2\/18), but <jats:styled-content style=\"fixed-case\">HAPS<\/jats:styled-content> could be induced by bisacodyl in 16 of 18 children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Children with chronic intractable constipation show a similar impaired postprandial colonic response to that seen in adults with slow\u2010transit constipation. Children may have attenuated extrinsic parasympathetic inputs to the colon associated with an increased incidence of spontaneous long\u2010single motor patterns.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12771","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T12:08:59Z","timestamp":1455278939000},"page":"743-757","source":"Crossref","is-referenced-by-count":44,"title":["Characterizing colonic motility in children with chronic intractable constipation: a look beyond high\u2010amplitude propagating sequences"],"prefix":"10.1111","volume":"28","author":[{"given":"S.","family":"Wessel","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Emma Children's Hospital\/Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. J. N.","family":"Koppen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Emma Children's Hospital\/Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wiklendt","sequence":"additional","affiliation":[{"name":"Department of Human Physiology Flinders University Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Human Physiology Flinders University Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Benninga","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology and Nutrition Emma Children's Hospital\/Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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