{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:30:22Z","timestamp":1776893422099,"version":"3.51.2"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:00:00Z","timestamp":1455235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"National Institute on Handicapped Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Functional constipation (FC<\/jats:styled-content>) and irritable bowel syndrome with constipation (IBS<\/jats:styled-content>\u2010C) share many symptoms but underlying mechanisms may be different. We have developed a magnetic resonance imaging (MRI<\/jats:styled-content>) technique to measure intestinal volumes, transit, and motility in response to a laxative, Moviprep\u00ae<\/jats:sup>. We aim to use these biomarkers to study the pathophysiology in IBS<\/jats:styled-content>\u2010C and FC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty\u2010four FC<\/jats:styled-content> and 24 IBS<\/jats:styled-content>\u2010C were studied. Transit was assessed using the weighted average position score (WAPS<\/jats:styled-content>) of five MRI<\/jats:styled-content> marker pills, taken 24 h before MRI<\/jats:styled-content> scanning. Following baseline scan, participants ingested 1 L of Moviprep\u00ae<\/jats:sup> followed by hourly scans. Magnetic resonance imaging parameters and bowel symptoms were scored from 0 to 4 h.<\/jats:p><\/jats:sec>Key Results<\/jats:title>Weighted average position score for FC<\/jats:styled-content> was 3.6 (2.5\u20134.2), significantly greater than IBS<\/jats:styled-content>\u2010C at 2.0 (1.5\u20133.2), p<\/jats:italic> = 0.01, indicating slower transit for FC. Functional constipation showed greater fasting small bowel water content, 83 (63\u2013142) mL vs<\/jats:italic> 39 (15\u201370) mL in IBS<\/jats:styled-content>\u2010C, p<\/jats:italic> < 0.01 and greater ascending colon volume (AC<\/jats:styled-content>), 314 (101) mL vs<\/jats:italic> 226 (71) mL in IBS<\/jats:styled-content>\u2010C, p<\/jats:italic> < 0.01. FC<\/jats:styled-content> motility index was lower at 0.055 (0.044) compared to IBS<\/jats:styled-content>\u2010C, 0.107 (0.070), p<\/jats:italic> < 0.01. Time to first bowel movement following ingestion of Moviprep\u00ae<\/jats:sup> was greater for FC<\/jats:styled-content>, being 295 (116\u2013526) min, compared to IBS<\/jats:styled-content>\u2010C at 84 (49\u2013111) min, p<\/jats:italic> < 0.01, and correlated with AC<\/jats:styled-content> volume 2 h after Moviprep\u00ae<\/jats:sup>, r<\/jats:italic> = 0.44, p<\/jats:italic> < 0.01. Using a cut\u2010off >230 min distinguishes FC<\/jats:styled-content> from IBS<\/jats:styled-content>\u2010C with low sensitivity of 55% but high specificity of 95%.<\/jats:p><\/jats:sec>Conclusion & Inferences<\/jats:title>Our objective MRI<\/jats:styled-content> biomarkers allow a distinction between FC<\/jats:styled-content> and IBS<\/jats:styled-content>\u2010C.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12784","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T15:08:46Z","timestamp":1455289726000},"page":"861-870","source":"Crossref","is-referenced-by-count":56,"title":["Colonic response to laxative ingestion as assessed by MRI<\/scp> differs in constipated irritable bowel syndrome compared to functional constipation"],"prefix":"10.1111","volume":"28","author":[{"given":"C.","family":"Lam","sequence":"first","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Biomedical Research Unit and Nottingham Digestive Diseases Centre School of Medicine University of Nottingham Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Chaddock","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre University of Nottingham Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Marciani","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Biomedical Research Unit and Nottingham Digestive Diseases Centre School of Medicine University of Nottingham Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Costigan","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Biomedical Research Unit and Nottingham Digestive Diseases Centre School of Medicine University of Nottingham Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Paul","sequence":"additional","affiliation":[{"name":"Sir Peter 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