{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:29:59Z","timestamp":1773008999681,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T00:00:00Z","timestamp":1454457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["INT 15\/00026"],"award-info":[{"award-number":["INT 15\/00026"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2014 SGR 789"],"award-info":[{"award-number":["2014 SGR 789"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Levosulpiride is a 5<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content><jats:sub>4<\/jats:sub> agonist\/D<jats:sub>2<\/jats:sub> antagonist prokinetic agent used to improve gastric emptying in patients with functional dyspepsia or gastroparesis. The aim of this study was to characterize its effect on the main <jats:italic>in vitro<\/jats:italic> motility patterns in the human fundus, antrum, and jejunum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Circular muscle strips from human stomach (antrum and fundus) and jejunum, obtained from 46 patients undergoing bariatric surgery, were studied using organ baths. Enteric motor neurons (<jats:styled-content style=\"fixed-case\">EMN<\/jats:styled-content>s) were stimulated by electrical field stimulation (<jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Levosulpiride, caused an increase in the <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>\u2010induced cholinergic contractions in the gastric antrum (+37 \u00b1 15.18% at 100 <jats:italic>\u03bc<\/jats:italic>M, <jats:styled-content style=\"fixed-case\">pEC<\/jats:styled-content><jats:sub>50<\/jats:sub> = 4.46 \u00b1 0.14; <jats:italic>p<\/jats:italic> &lt; 0.05, <jats:italic>n<\/jats:italic> = 8) and jejunum (+45.4 \u00b1 22.03% at 100 <jats:italic>\u03bc<\/jats:italic>M, <jats:styled-content style=\"fixed-case\">pEC<\/jats:styled-content><jats:sub>50<\/jats:sub> = 3.78 \u00b1 6.81; <jats:italic>p<\/jats:italic> &lt; 0.05, <jats:italic>n<\/jats:italic> = 5), but not in the gastric fundus. It also caused a slight decrease in tone and frequency of spontaneous contractions in the jejunum, but did not have any major effect on tone or spontaneous contractions in the stomach. It did not have any effect on <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>\u2010induced relaxations mediated by nitric oxide (<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content>) in the stomach (antrum and fundus) and by <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> in the jejunum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>Our results suggest that the prokinetic effects of levosulpiride in humans are mainly due to the facilitation of the release of acetylcholine by enteric motor neurons in the gastric antrum and the jejunum.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12788","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T04:07:26Z","timestamp":1454558846000},"page":"879-890","source":"Crossref","is-referenced-by-count":9,"title":["The effect of levosulpiride on 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