{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:47:52Z","timestamp":1791384472551,"version":"4.3.3"},"reference-count":75,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T00:00:00Z","timestamp":1457049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["607652"],"award-info":[{"award-number":["607652"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      There is increasing evidence in support of the presence of abnormal central changes (compared to healthy controls) in functional dyspepsia (\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      ) in addition to the peripheral changes in gastrointestinal tract.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      This systematic review aims to provide an integrative understanding of the abnormal functional brain activity, visceral sensation, dyspeptic symptoms, and psychological changes of\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      . Electronic and hand searches were conducted to identify functional neuroimaging studies involving\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      patients. Sixteen studies were selected and divided into three categories: 10 resting state studies, three visceral distention studies, and three acupuncture studies. Changes were reported in several brain areas in\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      patients including the frontal cortex, somatosensory cortex, insula, anterior cingulate cortex, thalamus, hippocampus, and amygdala. These brain activity changes were associated with visceral hypersensitivity, dyspeptic symptoms, poorer quality of life, anxiety, and depression. The results show that\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      is associated with functional abnormalities in sensory and pain modulation, emotion, saliency, and homeostatic processing regions. The diversity of conditions, heterogeneous results, poorly standardized diagnoses of\n                      <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>\n                      , and various comorbidities may be responsible for the variability in the results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nmo.12793","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T11:57:46Z","timestamp":1457179066000},"page":"793-805","source":"Crossref","is-referenced-by-count":104,"title":["Functional neuroimaging studies in functional dyspepsia patients: a systematic review"],"prefix":"10.1111","volume":"28","author":[{"given":"I.\u2010S.","family":"Lee","sequence":"first","affiliation":[{"name":"Psychosomatic Medicine and Psychotherapy Department University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"Graduate Training Centre of Neuroscience IMPRS for Cognitive and Systems Neuroscience T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wang","sequence":"additional","affiliation":[{"name":"Psychosomatic Medicine and Psychotherapy Department University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"Graduate Training Centre of Neuroscience IMPRS for Cognitive and Systems Neuroscience T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chae","sequence":"additional","affiliation":[{"name":"Acupuncture and Meridian Science Research Center College of Korean Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Preissl","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases Helmholtz Center Munich at the University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"German Center for Diabetes Research T\u00fcbingen Germany"},{"name":"Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry Department of Internal Medicine University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"Department Pharmacy and Biochemistry Faculty of Science University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Enck","sequence":"additional","affiliation":[{"name":"Psychosomatic Medicine and Psychotherapy Department University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"e_1_2_11_3_1","first-page":"237","article-title":"Rome III: new standard for functional gastrointestinal disorders","volume":"15","author":"Drossman DA","year":"2006","journal-title":"J Gastrointestin Liver 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