{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:13:54Z","timestamp":1762899234067},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24DK082792A"],"award-info":[{"award-number":["K24DK082792A"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with urinary incontinence (<jats:styled-content style=\"fixed-case\">UI<\/jats:styled-content>) have associated functional constipation (<jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>) and fecal incontinence (<jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>). The physiology between lower urinary tract (<jats:styled-content style=\"fixed-case\">LUT<\/jats:styled-content>) and anorectum in children has not been elucidated. Aims: Observe the effect of rectal distention (<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>) on <jats:styled-content style=\"fixed-case\">LUT<\/jats:styled-content> function, and bladder filling and voiding on anorectal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children with voiding dysfunction referred to Boston Children's Hospital were prospectively enrolled in combined urodynamic (<jats:styled-content style=\"fixed-case\">UDS<\/jats:styled-content>) and anorectal manometry (<jats:styled-content style=\"fixed-case\">ARM<\/jats:styled-content>). Anorectal and urodynamic parameters were simultaneously measured. Patients underwent two micturition cycles, first with rectal balloon deflated and second with it inflated (<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>). Lower urinary tract and anorectal parameters were compared between cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Ten children (seven <jats:styled-content style=\"fixed-case\">UI<\/jats:styled-content>, four recurrent <jats:styled-content style=\"fixed-case\">UTI<\/jats:styled-content>s, nine <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> \u00b1 <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>) were enrolled. Postvoid residual (<jats:styled-content style=\"fixed-case\">PVR<\/jats:styled-content>) increased (<jats:italic>p<\/jats:italic> = 0.02) with <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>. No differences were observed in percent of bladder filling to expected bladder capacity, sensation, and bladder compliance with and without <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>. Bladder and abdominal pressures increased at voiding with <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> (<jats:italic>p<\/jats:italic> &lt; 0.05). Intra\u2010anal pressures decreased at voiding (<jats:italic>p<\/jats:italic> &lt; 0.05), at 25% (<jats:italic>p<\/jats:italic> = 0.03) and 50% (<jats:italic>p<\/jats:italic> = 0.06) of total volume of bladder filling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Inferences<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">PVR<\/jats:styled-content> volume increased with <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>. Stool in the rectum does not alter filling cystometric capacity but decreases the bladder's ability to empty predisposing patients with fecal retention to <jats:styled-content style=\"fixed-case\">UI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">UTI<\/jats:styled-content>s. Bladder and abdominal pressures increased during voiding, demonstrating a physiological correlate of voiding dysfunction. Intra\u2010anal pressures decreased during bladder filling and voiding. This is the first time intra\u2010anal relaxation during bladder filling and voiding has been described.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12794","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T09:00:06Z","timestamp":1456822806000},"page":"924-933","source":"Crossref","is-referenced-by-count":12,"title":["Simultaneous urodynamic and anorectal manometry studies in children: insights into the relationship between the lower gastrointestinal and lower urinary tracts"],"prefix":"10.1111","volume":"28","author":[{"given":"L.","family":"Ambartsumyan","sequence":"first","affiliation":[{"name":"Center for Motility and Functional Gastrointestinal Disorders Boston Children's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Center for Motility and Functional Gastrointestinal Disorders Boston Children's Hospital Boston MA 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