{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:56:19Z","timestamp":1790517379416,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T00:00:00Z","timestamp":1466726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Methusalem grant from Leuven University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Rome<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>introduced a subdivision of functional dyspepsia (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>) into postprandial distress syndrome and epigastric pain syndrome, characterized by early satiation\/postprandial fullness, and epigastric pain\/burning, respectively. However, evidence on their degree of overlap is mixed. We aimed to investigate the latent structure of<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>to test whether distinguishable symptom\u2010based subgroups exist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive tertiary care Rome<jats:styled-content style=\"fixed-case\">II FD<\/jats:styled-content>patients completed the dyspepsia symptom severity scale. Confirmatory factor analysis (<jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content>) was used to compare the fit of a single factor model, a correlated three\u2010factor model based on Rome<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>subgroups and a bifactor model consisting of a general<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>factor and orthogonal subgroup factors. Taxometric analyses were subsequently used to investigate the latent structure of<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Nine hundred and fifty\u2010seven<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>patients (71.1% women, age 41\u00a0\u00b1\u00a014.8) participated. In<jats:styled-content style=\"fixed-case\">CFA<\/jats:styled-content>, the bifactor model yielded a significantly better fit than the two other models (<jats:italic>\u03c7<\/jats:italic>\u00b2 difference tests both<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). All symptoms had significant loadings on both the general and the subgroup\u2010specific factors (all<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Somatization was associated with the general (<jats:italic>r\u00a0<\/jats:italic>=\u00a00.72,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), but not the subgroup\u2010specific factors (all<jats:italic>r<\/jats:italic>\u00a0&lt;\u00a00.13,<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). Taxometric analyses supported a dimensional structure of<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>(all<jats:styled-content style=\"fixed-case\">CCFI<\/jats:styled-content>&lt;0.38).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Inferences<\/jats:title><jats:p>We found a dimensional rather than categorical latent structure of the<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>symptom complex in tertiary care. A combination of a general dyspepsia symptom reporting factor, which was associated with somatization, and symptom\u2010specific factors reflecting the Rome<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>subdivision fitted the data best. This has implications for classification, pathophysiology, and treatment of<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nmo.12798","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T21:43:29Z","timestamp":1466891009000},"page":"985-993","source":"Crossref","is-referenced-by-count":9,"title":["The latent structure of the functional dyspepsia symptom complex: a taxometric analysis"],"prefix":"10.1111","volume":"28","author":[{"given":"L.","family":"Van Oudenhove","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine Translational Research Centre for Gastrointestinal Disorders (TARGID) University of Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Jasper","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychotherapy Johannes Gutenberg University Mainz 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